|Publication type:||Book part|
|Type of review:||Not specified|
|Title:||Single‐use bioreactors : an overview|
|Published in:||Single‐Use Technology in Biopharmaceutical Manufacture|
|Publisher / Ed. Institution:||Wiley|
|Subject (DDC):||660: Chemical engineering|
|Abstract:||This chapter aims to give an overview of instrumented single‐use bioreactor (SUB) types that are currently available commercially. Based on the milestones in the development of SUBs, it focuses on the three most often applied types: wave‐mixed, stirred, and orbitally shaken versions. Their typical working principles are explained, possible fields of application are deduced, and trends in their selection are summarized. The development of SUBs can be described in three phases: the early beginnings; the establishment of disposable membrane bioreactors, multitray cell culture systems, and the first bag bioreactors; and the expansion of wave‐mixed, stirred, orbitally shaken, and further SUBs. The most suitable bioreactor for a desired application depends on several factors. The selection of the bioreactor is significantly influenced by the cultivation task, the engineering parameters of the bioreactor, the scale, the production organism, the legal requirements, the infrastructure, the know‐how of staff, and the costs for investment and operation.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.