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Title: In vivo confirmation of hydration-induced changes in human-skin thickness, roughness and interaction with the environment
Authors : Dabrowska, Agnieszka K.
Adlhart, Christian
Spano, Fabriziano
Rotaru, Gelu-Marius
Derler, Siegfried
Zhai, Lina
Spencer, Nicolas D.
Rossi, René M.
Published in : Biointerphases
Volume(Issue) : 11
Issue : 3
Publisher / Ed. Institution : A I P Publishing LLC
Publisher / Ed. Institution: Maryland
Issue Date: Aug-2016
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Type of review: Peer review (Publication)
Language : English
Subjects : Skin; Raman spectra; Spectral properties; Three dimensional microscopy; Proteins
Subject (DDC) : 610: Medicine and health
Abstract: Skin properties, structure and performance can be influenced by many internal and external factors, such as age, gender, lifestyle, skin diseases and a hydration level that can vary in relation to the environment. The aim of this work was to demonstrate the multifaceted influence of water on human skin through a combination of in vivo confocal Raman spectroscopy and images of volar-forearm skin captured with laser scanning confocal microscopy. By means of this pilot study, we have both qualitatively and quantitatively studied the influence of changing the depth-dependent hydration level of the stratum corneum (SC) on the real contact area (RCA), surface roughness and the dimensions of the primary lines and presented a new method for characterising the contact area for different states of the skin. The hydration level of the skin and the thickness of the SC increased significantly due to uptake of moisture derived from liquid water or, to a much lesser extent, from humidity present in the environment. Hydrated skin was smoother and exhibited higher RCA values. The highest rates of water uptake were observed for the upper few μm of skin and for short exposure times.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1116/1.4962547
ISSN: 1934-8630
Appears in Collections:Publikationen Life Sciences und Facility Management

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