| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Design and structural evolution of matrix metalloproteinase inhibitors |
| Autor/-in: | Fischer, Thomas Senn, Nicole Riedl, Rainer |
| et. al: | No |
| DOI: | 10.1002/chem.201805361 |
| Erschienen in: | Chemistry – A European Journal |
| Band(Heft): | 25 |
| Heft: | 34 |
| Seite(n): | 7960 |
| Seiten bis: | 7980 |
| Erscheinungsdatum: | 5-Feb-2019 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 0947-6539 1521-3765 |
| Sprache: | Englisch |
| Schlagwörter: | Drug desgin; Drug discovery; Inhibitors; Medicinal chemistry; Metalloenzyme; Animal; Human; Matrix metalloproteinase inhibitors; Matrix metalloproteinases; Molecular model; Structure-activity relationship |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | Matrix metalloproteinases (MMPs) are involved in a multitude of severe diseases. Despite MMPs being considered druggable targets, past drug-discovery programs have not delivered the anticipated clinical benefits. This review examines the latest structural evolution of small-molecule inhibitors of MMPs, with a focus on the development of novel chemical entities with improved affinity and selectivity profiles. X-ray crystallographic data of the protein targets and cocrystal structures with inhibitors proved to be key for the success achieved during this ambitious endeavor. An evolutionary view on the structural diversity generated for this class of molecules is provided. This encouraging development paves the way for the clinical utilization of this class of highly relevant therapeutic targets. The structure-based design of superior MMP inhibitors highlights the power of this technique and displays strategies for the development of treatment options based on the modulation of challenging drug targets. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21750 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Fischer, T., Senn, N., & Riedl, R. (2019). Design and structural evolution of matrix metalloproteinase inhibitors. Chemistry – A European Journal, 25(34), 7960–7980. https://doi.org/10.1002/chem.201805361
Fischer, T., Senn, N. and Riedl, R. (2019) ‘Design and structural evolution of matrix metalloproteinase inhibitors’, Chemistry – A European Journal, 25(34), pp. 7960–7980. Available at: https://doi.org/10.1002/chem.201805361.
T. Fischer, N. Senn, and R. Riedl, “Design and structural evolution of matrix metalloproteinase inhibitors,” Chemistry – A European Journal, vol. 25, no. 34, pp. 7960–7980, Feb. 2019, doi: 10.1002/chem.201805361.
FISCHER, Thomas, Nicole SENN und Rainer RIEDL, 2019. Design and structural evolution of matrix metalloproteinase inhibitors. Chemistry – A European Journal. 5 Februar 2019. Bd. 25, Nr. 34, S. 7960–7980. DOI 10.1002/chem.201805361
Fischer, Thomas, Nicole Senn, and Rainer Riedl. 2019. “Design and Structural Evolution of Matrix Metalloproteinase Inhibitors.” Chemistry – A European Journal 25 (34): 7960–80. https://doi.org/10.1002/chem.201805361.
Fischer, Thomas, et al. “Design and Structural Evolution of Matrix Metalloproteinase Inhibitors.” Chemistry – A European Journal, vol. 25, no. 34, Feb. 2019, pp. 7960–80, https://doi.org/10.1002/chem.201805361.
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