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dc.contributor.authorAgnello, Stefano-
dc.contributor.authorBrand, Michael-
dc.contributor.authorChellat, Mathieu-
dc.contributor.authorGazzola, Silvia-
dc.contributor.authorRiedl, Rainer-
dc.date.accessioned2021-02-18T10:36:39Z-
dc.date.available2021-02-18T10:36:39Z-
dc.date.issued2018-05-30-
dc.identifier.issn0044-8249de_CH
dc.identifier.issn1521-3773de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21747-
dc.description.abstractThe natural phenomenon of drug resistance is a widespread issue that hampers the performance of drugs in many major clinical indications. Antibacterial and antifungal drugs are affected, as well as compounds for the treatment of cancer, viral infections, or parasitic diseases. Despite the very diverse set of biological targets and organisms involved in the development of drug resistance, the underlying molecular mechanisms have been identified to understand the emergence of resistance and to overcome this detrimental process. Detailed structural information on the root causes for drug resistance is nowadays frequently available, so next-generation drugs can be designed that are anticipated to suffer less from resistance. This knowledge-based approach is essential for fighting the inevitable occurrence of drug resistance.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofAngewandte Chemiede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectDrug discoveryde_CH
dc.subjectDrug resistancede_CH
dc.subjectMedicinal chemistryde_CH
dc.subjectStructure-activity relationshipsde_CH
dc.subjectStructure-based drug designde_CH
dc.subjectAnimalsde_CH
dc.subjectAnti-HIV Agentsde_CH
dc.subjectAnti-infective agentsde_CH
dc.subjectAntimalarialsde_CH
dc.subjectAntineoplastic agentsde_CH
dc.subjectDrug designde_CH
dc.subjectHumansde_CH
dc.subjectMolecular modelsde_CH
dc.subjectMolecular structurede_CH
dc.subjectProtein bindingde_CH
dc.subjectSignal transductionde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleA Structural view on medicinal chemistry strategies against drug resistancede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/anie.201802416de_CH
dc.identifier.pmid29846032de_CH
zhaw.funding.euNode_CH
zhaw.issue11de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end3345de_CH
zhaw.pages.start3300de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume58de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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