| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | A Structural view on medicinal chemistry strategies against drug resistance |
| Autor/-in: | Agnello, Stefano Brand, Michael Chellat, Mathieu Gazzola, Silvia Riedl, Rainer |
| et. al: | No |
| DOI: | 10.1002/anie.201802416 |
| Erschienen in: | Angewandte Chemie |
| Band(Heft): | 58 |
| Heft: | 11 |
| Seite(n): | 3300 |
| Seiten bis: | 3345 |
| Erscheinungsdatum: | 30-Mai-2018 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 0044-8249 1521-3773 |
| Sprache: | Englisch |
| Schlagwörter: | Drug discovery; Drug resistance; Medicinal chemistry; Structure-activity relationships; Structure-based drug design; Animals; Anti-HIV Agents; Anti-infective agents; Antimalarials; Antineoplastic agents; Drug design; Humans; Molecular models; Molecular structure; Protein binding; Signal transduction |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | The natural phenomenon of drug resistance is a widespread issue that hampers the performance of drugs in many major clinical indications. Antibacterial and antifungal drugs are affected, as well as compounds for the treatment of cancer, viral infections, or parasitic diseases. Despite the very diverse set of biological targets and organisms involved in the development of drug resistance, the underlying molecular mechanisms have been identified to understand the emergence of resistance and to overcome this detrimental process. Detailed structural information on the root causes for drug resistance is nowadays frequently available, so next-generation drugs can be designed that are anticipated to suffer less from resistance. This knowledge-based approach is essential for fighting the inevitable occurrence of drug resistance. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21747 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Zur Langanzeige
Agnello, S., Brand, M., Chellat, M., Gazzola, S., & Riedl, R. (2018). A Structural view on medicinal chemistry strategies against drug resistance. Angewandte Chemie, 58(11), 3300–3345. https://doi.org/10.1002/anie.201802416
Agnello, S. et al. (2018) ‘A Structural view on medicinal chemistry strategies against drug resistance’, Angewandte Chemie, 58(11), pp. 3300–3345. Available at: https://doi.org/10.1002/anie.201802416.
S. Agnello, M. Brand, M. Chellat, S. Gazzola, and R. Riedl, “A Structural view on medicinal chemistry strategies against drug resistance,” Angewandte Chemie, vol. 58, no. 11, pp. 3300–3345, May 2018, doi: 10.1002/anie.201802416.
AGNELLO, Stefano, Michael BRAND, Mathieu CHELLAT, Silvia GAZZOLA und Rainer RIEDL, 2018. A Structural view on medicinal chemistry strategies against drug resistance. Angewandte Chemie. 30 Mai 2018. Bd. 58, Nr. 11, S. 3300–3345. DOI 10.1002/anie.201802416
Agnello, Stefano, Michael Brand, Mathieu Chellat, Silvia Gazzola, and Rainer Riedl. 2018. “A Structural View on Medicinal Chemistry Strategies against Drug Resistance.” Angewandte Chemie 58 (11): 3300–3345. https://doi.org/10.1002/anie.201802416.
Agnello, Stefano, et al. “A Structural View on Medicinal Chemistry Strategies against Drug Resistance.” Angewandte Chemie, vol. 58, no. 11, May 2018, pp. 3300–45, https://doi.org/10.1002/anie.201802416.
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