Publication type: Patent
Title: Composition for treatment of pathogens that are resistant to tetracyclines
Inventor: Schneider, Peter
Riedl, Rainer
Tigges, Marcel
Gitzinger, Marc
Pieren, Michel
Levi, Assaf
Sephton, Mark
Schellhorn, Birgit
Züger, Patrik
Brand, Michael
Gygax, Daniel
Spies, Peter
Patent submitter: BioVersys AG
Issue Date: 9-Dec-2015
Publication number: EP2950793
metadata.zhaw.publication.code: A1
Published as: EP2762134A1; EP2950793B1; US2015359791A1; US9682079B2; WO2014118361A1
Language: English
Abstract: The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram- positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Patente Life Sciences und Facility Management

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