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Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Peer review (Publikation)
Titel: Shape irregularity of the intracranial aneurysm lumen exhibits diagnostic value
Autor/-in: Juchler, Norman
Schilling, Sabine
Bijlenga, Philippe
Morel, Sandrine
Rüfenacht, Daniel
Kurtcuoglu, Vartan
Hirsch, Sven
et. al: No
DOI: 10.1007/s00701-020-04428-0
10.21256/zhaw-21579
Erschienen in: Acta Neurochirurgica
Band(Heft): 162
Heft: 9
Seite(n): 2261
Seiten bis: 2270
Erscheinungsdatum: 4-Jun-2020
Verlag / Hrsg. Institution: Springer
ISSN: 0001-6268
0942-0940
Sprache: Englisch
Schlagwörter: Intracranial aneurysm; Irregularity; Quantitative morphology; Rating study
Fachgebiet (DDC): 616: Innere Medizin und Krankheiten
Zusammenfassung: Background: Morphological irregularity is linked to intracranial aneurysm wall instability and manifests in the lumen shape. Yet there is currently no consent on how to assess shape irregularity. The aims of this work are to quantify irregularity as perceived by clinicians, to break down irregularity into morphological attributes, and to relate these to clinically relevant factors such as rupture status, aneurysm location, and patient age or sex. Methods: Thirteen clinicians and 26 laypersons assessed 134 aneurysm lumen segmentations in terms of overall perceived irregularity and five different morphological attributes (presence/absence of a rough surface, blebs, lobules, asymmetry, complex geometry of the parent vasculature). We examined rater agreement and compared the ratings with clinical factors by means of regression analysis or binary classification. Results: Using rank-based aggregation, the irregularity ratings of clinicians and laypersons did not differ statistically. Perceived irregularity showed good agreement with curvature (coefficient of determination R2 = 0.68 ± 0.08) and was modeled very accurately using the five morphological rating attributes plus shape elongation (R2 = 0.95 ± 0.02). In agreement with previous studies, irregularity was associated with aneurysm rupture status (AUC = 0.81 ± 0.08); adding aneurysm location as an explanatory variable increased the AUC to 0.87 ± 0.09. Besides irregularity, perceived asymmetry, presence of blebs or lobules, aneurysm size, non-sphericity, and curvature were linked to rupture. No association was found between morphology and any of patient sex, age, and history of smoking or hypertension. Aneurysm size was linked to morphology. Conclusions: Irregular lumen shape carries significant information on the aneurysm’s disease status. Irregularity constitutes a continuous parameter that shows a strong association with the rupture status. To improve the objectivity of morphological assessment, we suggest examining shape through six different morphological attributes, which can characterize irregularity accurately.
Weitere Angaben: Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)
URI: https://digitalcollection.zhaw.ch/handle/11475/21579
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): Lizenz gemäss Verlagsvertrag
Gesperrt bis: 2025-10-01
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Computational Life Sciences (ICLS)
Publiziert im Rahmen des ZHAW-Projekts: AneuX
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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2020_Juchler-etal_Shape-irregularity-intracranial-aneurysm-lumen.pdf
  Bis 2025-10-01
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