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dc.contributor.authorKönigstein, Karsten-
dc.contributor.authorvon Schenck, Ursula-
dc.contributor.authorBüschges, Julia Charlotte-
dc.contributor.authorSchweizer, Dieter-
dc.contributor.authorVogelgesang, Felicitas-
dc.contributor.authorDamerow, Stefan-
dc.contributor.authorSarganas, Giselle-
dc.contributor.authorDratva, Julia-
dc.contributor.authorSchmidt-Trucksäss, Arno-
dc.contributor.authorNeuhauser, Hannelore-
dc.date.accessioned2021-02-04T08:31:55Z-
dc.date.available2021-02-04T08:31:55Z-
dc.date.issued2020-11-19-
dc.identifier.issn0301-5629de_CH
dc.identifier.issn1879-291Xde_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21515-
dc.description.abstractCarotid intima-media thickness (cIMT) and carotid stiffness (CS) are important markers of atherosclerotic risk in the young. We assessed a novel third-generation method for its applicability in large population-based epidemiologic studies to determine strengths, limitations, completeness and predictors of unsuccessful measurement. Four thousand seven hundred ninety-eight 14- to 31-y-old participants of the German KiGGS cohort, which is based on a nationally representative sample with 11-y follow-up, underwent B-mode ultrasound examinations of the left and right common carotid artery with semi-automatic edge detection and automatic electrocardiogram-gated real-time quality control based on a sophisticated snake algorithm and subpixel interpolation. Overall completeness was 98% for far wall cIMT and 89% for CS parameters. Plane-specific completeness varied from 92%-96% for far wall and from 64%-69% for near-wall cIMT. Obesity independently predicted unsuccessful cIMT and CS measurements with odds ratios of 12.67 (95% confidence interval: 5.50-29.19) and 7.30 (4.87-10.94) compared with non-overweight after adjustment for blood pressure, cholesterol, smoking, hazardous drinking, age, sex and sonographer. Inter- and intra-rater reliabilities of cIMT and CS parameters in a sample of 15 young adults were good or excellent. Third-generation cIMT and CS measurements in the young with semi-automatic edge-detection and automatic real-time quality control has been successfully standardized with high reliability and very high completeness in a national survey setting. This provides a strong methodological foundation for further validation of the predictive value of cIMT and CS for atherosclerotic risk in the young.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofUltrasound in Medicine & Biologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectIntima–media thicknessde_CH
dc.subjectObesityde_CH
dc.subjectStiffnessde_CH
dc.subjectUltrasoundde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleCarotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completenessde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Gesundheitswissenschaften (IGW)de_CH
dc.identifier.doi10.1016/j.ultrasmedbio.2020.10.015de_CH
dc.identifier.pmid33221140de_CH
zhaw.funding.euNode_CH
zhaw.issue2de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end308de_CH
zhaw.pages.start296de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume47de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedG: Gesundheit von Kindern und Jugendlichende_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Gesundheit

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