Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Carotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completeness
Authors: Königstein, Karsten
von Schenck, Ursula
Büschges, Julia Charlotte
Schweizer, Dieter
Vogelgesang, Felicitas
Damerow, Stefan
Sarganas, Giselle
Dratva, Julia
Schmidt-Trucksäss, Arno
Neuhauser, Hannelore
et. al: No
DOI: 10.1016/j.ultrasmedbio.2020.10.015
Published in: Ultrasound in Medicine & Biology
Volume(Issue): 47
Issue: 2
Pages: 296
Pages to: 308
Issue Date: 19-Nov-2020
Publisher / Ed. Institution: Elsevier
ISSN: 0301-5629
Language: English
Subjects: Intima–media thickness; Obesity; Stiffness; Ultrasound
Subject (DDC): 616: Internal medicine and diseases
Abstract: Carotid intima-media thickness (cIMT) and carotid stiffness (CS) are important markers of atherosclerotic risk in the young. We assessed a novel third-generation method for its applicability in large population-based epidemiologic studies to determine strengths, limitations, completeness and predictors of unsuccessful measurement. Four thousand seven hundred ninety-eight 14- to 31-y-old participants of the German KiGGS cohort, which is based on a nationally representative sample with 11-y follow-up, underwent B-mode ultrasound examinations of the left and right common carotid artery with semi-automatic edge detection and automatic electrocardiogram-gated real-time quality control based on a sophisticated snake algorithm and subpixel interpolation. Overall completeness was 98% for far wall cIMT and 89% for CS parameters. Plane-specific completeness varied from 92%-96% for far wall and from 64%-69% for near-wall cIMT. Obesity independently predicted unsuccessful cIMT and CS measurements with odds ratios of 12.67 (95% confidence interval: 5.50-29.19) and 7.30 (4.87-10.94) compared with non-overweight after adjustment for blood pressure, cholesterol, smoking, hazardous drinking, age, sex and sonographer. Inter- and intra-rater reliabilities of cIMT and CS parameters in a sample of 15 young adults were good or excellent. Third-generation cIMT and CS measurements in the young with semi-automatic edge-detection and automatic real-time quality control has been successfully standardized with high reliability and very high completeness in a national survey setting. This provides a strong methodological foundation for further validation of the predictive value of cIMT and CS for atherosclerotic risk in the young.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Health Professions
Organisational Unit: Institute of Health Sciences (IGW)
Appears in collections:Publikationen Gesundheit

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