|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Carotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completeness|
von Schenck, Ursula
Büschges, Julia Charlotte
|Published in:||Ultrasound in Medicine & Biology|
|Publisher / Ed. Institution:||Elsevier|
|Subjects:||Intima–media thickness; Obesity; Stiffness; Ultrasound|
|Subject (DDC):||616: Internal medicine and diseases|
|Abstract:||Carotid intima-media thickness (cIMT) and carotid stiffness (CS) are important markers of atherosclerotic risk in the young. We assessed a novel third-generation method for its applicability in large population-based epidemiologic studies to determine strengths, limitations, completeness and predictors of unsuccessful measurement. Four thousand seven hundred ninety-eight 14- to 31-y-old participants of the German KiGGS cohort, which is based on a nationally representative sample with 11-y follow-up, underwent B-mode ultrasound examinations of the left and right common carotid artery with semi-automatic edge detection and automatic electrocardiogram-gated real-time quality control based on a sophisticated snake algorithm and subpixel interpolation. Overall completeness was 98% for far wall cIMT and 89% for CS parameters. Plane-specific completeness varied from 92%-96% for far wall and from 64%-69% for near-wall cIMT. Obesity independently predicted unsuccessful cIMT and CS measurements with odds ratios of 12.67 (95% confidence interval: 5.50-29.19) and 7.30 (4.87-10.94) compared with non-overweight after adjustment for blood pressure, cholesterol, smoking, hazardous drinking, age, sex and sonographer. Inter- and intra-rater reliabilities of cIMT and CS parameters in a sample of 15 young adults were good or excellent. Third-generation cIMT and CS measurements in the young with semi-automatic edge-detection and automatic real-time quality control has been successfully standardized with high reliability and very high completeness in a national survey setting. This provides a strong methodological foundation for further validation of the predictive value of cIMT and CS for atherosclerotic risk in the young.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||School of Health Sciences|
|Organisational Unit:||Institute of Public Health (IPH)|
|Appears in collections:||Publikationen Gesundheit|
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Königstein, K., von Schenck, U., Büschges, J. C., Schweizer, D., Vogelgesang, F., Damerow, S., Sarganas, G., Dratva, J., Schmidt-Trucksäss, A., & Neuhauser, H. (2021). Carotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completeness. Ultrasound in Medicine & Biology, 47(2), 296–308. https://doi.org/10.1016/j.ultrasmedbio.2020.10.015
Königstein, K. et al. (2021) ‘Carotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completeness’, Ultrasound in Medicine & Biology, 47(2), pp. 296–308. Available at: https://doi.org/10.1016/j.ultrasmedbio.2020.10.015.
K. Königstein et al., “Carotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completeness,” Ultrasound in Medicine & Biology, vol. 47, no. 2, pp. 296–308, 2021, doi: 10.1016/j.ultrasmedbio.2020.10.015.
Königstein, Karsten, et al. “Carotid IMT and Stiffness in the KiGGS 2 National Survey : Third-Generation Measurement, Quality Algorithms and Determinants of Completeness.” Ultrasound in Medicine & Biology, vol. 47, no. 2, 2021, pp. 296–308, https://doi.org/10.1016/j.ultrasmedbio.2020.10.015.
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