| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Carotid IMT and stiffness in the KiGGS 2 national survey : third-generation measurement, quality algorithms and determinants of completeness |
| Authors: | Königstein, Karsten von Schenck, Ursula Büschges, Julia Charlotte Schweizer, Dieter Vogelgesang, Felicitas Damerow, Stefan Sarganas, Giselle Dratva, Julia Schmidt-Trucksäss, Arno Neuhauser, Hannelore |
| et. al: | No |
| DOI: | 10.1016/j.ultrasmedbio.2020.10.015 |
| Published in: | Ultrasound in Medicine & Biology |
| Volume(Issue): | 47 |
| Issue: | 2 |
| Pages: | 296 |
| Pages to: | 308 |
| Issue Date: | 19-Nov-2020 |
| Publisher / Ed. Institution: | Elsevier |
| ISSN: | 0301-5629 1879-291X |
| Language: | English |
| Subjects: | Intima–media thickness; Obesity; Stiffness; Ultrasound |
| Subject (DDC): | 616: Internal medicine and diseases |
| Abstract: | Carotid intima-media thickness (cIMT) and carotid stiffness (CS) are important markers of atherosclerotic risk in the young. We assessed a novel third-generation method for its applicability in large population-based epidemiologic studies to determine strengths, limitations, completeness and predictors of unsuccessful measurement. Four thousand seven hundred ninety-eight 14- to 31-y-old participants of the German KiGGS cohort, which is based on a nationally representative sample with 11-y follow-up, underwent B-mode ultrasound examinations of the left and right common carotid artery with semi-automatic edge detection and automatic electrocardiogram-gated real-time quality control based on a sophisticated snake algorithm and subpixel interpolation. Overall completeness was 98% for far wall cIMT and 89% for CS parameters. Plane-specific completeness varied from 92%-96% for far wall and from 64%-69% for near-wall cIMT. Obesity independently predicted unsuccessful cIMT and CS measurements with odds ratios of 12.67 (95% confidence interval: 5.50-29.19) and 7.30 (4.87-10.94) compared with non-overweight after adjustment for blood pressure, cholesterol, smoking, hazardous drinking, age, sex and sonographer. Inter- and intra-rater reliabilities of cIMT and CS parameters in a sample of 15 young adults were good or excellent. Third-generation cIMT and CS measurements in the young with semi-automatic edge-detection and automatic real-time quality control has been successfully standardized with high reliability and very high completeness in a national survey setting. This provides a strong methodological foundation for further validation of the predictive value of cIMT and CS for atherosclerotic risk in the young. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21515 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Health Professions |
| Organisational Unit: | Institute of Health Sciences (IGW) |
| Appears in collections: | Publikationen Gesundheit |
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