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Publication type: Conference poster
Type of review: Not specified
Title: CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer
Authors: Seidel, Stefan
Werner, Sören
Eibl, Dieter
et. al: No
DOI: 10.1002/cite.202055288
Published in: Chemie Ingenieur Technik
Proceedings: Special Issue : 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020
Pages: 1324
Conference details: 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 : Processes for Future, Web-Konferenz, 21.-24. September 2020
Issue Date: 24-Sep-2020
Publisher / Ed. Institution: Wiley
ISSN: 0009-286X
Language: English
Subjects: Bioreactor; CFD simulation; Multiphase modeling; Oxygen transfer rate; Population balance modeling
Subject (DDC): 660: Chemical engineering
Abstract: Oxygen supply of cells has a significant influence on cell growth and product yield. For this reason, biopharmaceutical manufacturers and their bioreactor suppliers are interested in optimizing the oxygen supply. In this context, computational fluid dynamics (CFD) can be used to calculate the kLa value in stirred bioreactors. First investigations have shown that both the volume-of-fluid (VOF) model and the compressible VOF model are unsuitable for the calculation of kLa values due to their lack of accuracy. Simulations with the Euler-Euler model showed significantly better agreement with experimental data, but the calculated kLa values were still about 50% higher than in the experiments. One reason could be the missing consideration of gas bubble breakup and coalescence. Therefore, various investigations were carried out with a population balance model (PBM)-coupled Euler-Euler model, which all were in better agreement with the experimental data, compared to the Euler-Euler model. With the help of the successfully established PBM-coupled CFD model it is now possible to calculate the oxygen mass transfer for stirred bioreactors. Thus, bioreactor and process design can be accomplished before prototyping, and time-consuming as well as cost-intensive laboratory experiments can be reduced. In order to verify the generality for all sizes of bioreactors, further validation work will be carried out.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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