Publication type: Conference other
Type of review: No review
Title: CFD for process engineering characterization
Authors: Seidel, Stefan
Werner, Sören
Eibl, Dieter
et. al: No
Conference details: Levitronix Bioprocessing Conference, Webinar Part 3, 10 June 2020
Issue Date: 10-Jun-2020
Language: English
Subjects: Bioreactor; CFD simulation; Multiphase modeling; Oxygen transfer rate; Population balance modeling
Subject (DDC): 660: Chemical engineering
Abstract: Computational Fluid Dynamics (CFD) is used in biotechnology to gain a deeper understanding of the underlying fluid flow in a great variety of process equipment, e.g. for fluid flow characterisation in bioreactors. This enables the reduction of resource-intensive prototyping, since CFD is used to determine optimal process conditions in silico. Typical process engineering investigations for bioreactors are mixing time, power input as well as shear and normal stress. Most of the biopharmaceutical production processes are accomplished with aerobe cells, and thus the process relies on sufficient gas mass transfer to supply enough oxygen to the culture broth, which has a considerable influence on cell growth and product yield. In recent years, CFD models have increasingly been coupled with population balance models (PBM) to calculate the gas bubble size distribution through breakup and coalescence. This coupling allows the simulation of oxygen distribution in polydisperse systems, like aerated bioreactors. This presentation shows recent developments in modelling bubble size distribution and gas mass transfer.
URI: https://www.levitronix.com/files/dl__documents/Levitronix%20Conferences/LBC%202020%20Webinar/EventAgendaJune10.pdf
https://digitalcollection.zhaw.ch/handle/11475/21013
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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