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https://doi.org/10.21256/zhaw-20996| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Biocatalysis in the Swiss manufacturing environment |
| Authors: | Hecht, Katrin Meyer, Hans-Peter Wohlgemuth, Roland Buller, Rebecca |
| et. al: | No |
| DOI: | 10.3390/catal10121420 10.21256/zhaw-20996 |
| Published in: | Catalysts |
| Volume(Issue): | 10 |
| Issue: | 12 |
| Page(s): | 1420 |
| Issue Date: | 2020 |
| Publisher / Ed. Institution: | MDPI |
| ISSN: | 2073-4344 |
| Language: | English |
| Subjects: | Industrial biocatalysis; Drug shortage; Enzyme technology; Switzerland |
| Subject (DDC): | 660.6: Biotechnology |
| Abstract: | Biocatalysis has undergone a remarkable transition in the last two decades, from being considered a niche technology to playing a much more relevant role in organic synthesis today. Advances in molecular biology and bioinformatics, and the decreasing costs for gene synthesis and sequencing contribute to the growing success of engineered biocatalysts in industrial applications [1]. However, the incorporation of biocatalytic process steps in new or established manufacturing routes is not always straightforward. To realize the full synthetic potential of biocatalysis for the sustainable manufacture of chemical building blocks, it is therefore important to regularly analyze the success factors and existing hurdles for the implementation of enzymes in large scale small molecule synthesis. Building on our previous analysis of biocatalysis in the Swiss manufacturing environment [2], we present a follow-up study on how the industrial biocatalysis situation in Switzerland has evolved in the last four years. Considering the current industrial landscape, we record recent advances in biocatalysis in Switzerland as well as give suggestions where enzymatic transformations may be valuably employed to address some of the societal challenges we face today, particularly in the context of the current Coronavirus disease 2019 (COVID-19) pandemic. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/20996 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2020_Hecht-etal_Biocatalysis-in-the-Swiss-manufacturing-environment.pdf | 1.81 MB | Adobe PDF |  View/Open |
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Hecht, K., Meyer, H.-P., Wohlgemuth, R., & Buller, R. (2020). Biocatalysis in the Swiss manufacturing environment. Catalysts, 10(12), 1420. https://doi.org/10.3390/catal10121420
Hecht, K. et al. (2020) ‘Biocatalysis in the Swiss manufacturing environment’, Catalysts, 10(12), p. 1420. Available at: https://doi.org/10.3390/catal10121420.
K. Hecht, H.-P. Meyer, R. Wohlgemuth, and R. Buller, “Biocatalysis in the Swiss manufacturing environment,” Catalysts, vol. 10, no. 12, p. 1420, 2020, doi: 10.3390/catal10121420.
HECHT, Katrin, Hans-Peter MEYER, Roland WOHLGEMUTH und Rebecca BULLER, 2020. Biocatalysis in the Swiss manufacturing environment. Catalysts. 2020. Bd. 10, Nr. 12, S. 1420. DOI 10.3390/catal10121420
Hecht, Katrin, Hans-Peter Meyer, Roland Wohlgemuth, and Rebecca Buller. 2020. “Biocatalysis in the Swiss Manufacturing Environment.” Catalysts 10 (12): 1420. https://doi.org/10.3390/catal10121420.
Hecht, Katrin, et al. “Biocatalysis in the Swiss Manufacturing Environment.” Catalysts, vol. 10, no. 12, 2020, p. 1420, https://doi.org/10.3390/catal10121420.
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