Title: Membrane-particle interactions in an asymmetric flow field flow fractionation channel studied with titanium dioxide nanoparticles
Authors : Bendixen, Nina
Losert, Sabrina
Adlhart, Christian
Lattuada, Marco
Ulrich, Andrea
Published in : Journal of Chromatography A
Volume(Issue) : 1334
Pages : 92
Pages to: 100
Publisher / Ed. Institution : Elsevier
Publisher / Ed. Institution: Amsterdam
Issue Date: 2014
Language : Englisch / English
Subjects : Membrane; Titanium dioxide nanoparticle; Interaction; Asymmetric flow field flow fractionation (A4F); Zeta-potential
Subject (DDC) : 620: Ingenieurwesen
Abstract: Asymmetric flow field flow fractionation operated in a multidetector approach (A4F-MDA) is a powerful tool to perform size-classified nanoparticle analysis. Recently several publications mentioned insufficient recovery rates and even retention time shifts attributed to unspecific membrane–particle interactions. One hypothesis to explain this phenomenon is based on the surface charge (zeta-potential) of the membrane material and the particle. In this study, we investigated in how far the ζ-potential of A4F membrane and particles would determine the outcome of A4F in terms of feasibility, separation efficiency, retention time, and recovery rate, or whether other factors such as membrane morphology and particle size were equally important. We systematically studied the influence of the ζ-potential on the interactions between the most commonly used A4F membrane materials and two representative types of titanium dioxide nanoparticles (TiO2 NP). Furthermore the effect of different carrier media and additional surfactants on the surface charge of membranes and particles was investigated and the influence of the particle size and the particle concentration on the recovery rate was evaluated. We found that the eligibility of an A4F method can be predicted based on the ζ-potential of the NPs and the A4F membrane. Furthermore knowing the ζ-potential allows to tuning the separation efficiency of an A4F method. On the other hand we observed significant shifts in retention time for different membrane materials that impede the determination of particle size based on the classical A4F theory. These shifts cannot be attributed to the ζ-potential. Also the ζ-potential does not account for varying recovery rates of different particle types, instead the particle size seems to be the limiting factor. Therefore, the proper characterization of a polydisperse sample remains a challenge.
Departement: Life Sciences und Facility Management
Organisational Unit: Institut für Chemie und Biotechnologie (ICBT)
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
Type of review: Peer review (Publikation)
DOI : 10.1016/j.chroma.2014.01.066
ISSN: 0021-9673
URI: https://digitalcollection.zhaw.ch/handle/11475/2080
License (according to publishing contract) : Lizenz gemäss Verlagsvertrag / Licence according to publishing contract
Appears in Collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.