Title: Critical aspects of sample handling for direct nanoparticle analysis and analytical challenges using asymmetric field flow fractionation in a multi-detector approach
Authors : Ulrich, A.
Losert, S.
Bendixen, Nina
Al-Kattan, A.
Hagendorfer, H.
Nowack, B.
Adlhart, Christian
Ebert, Jürgen
Lattuada, M.
Hungerbühler, Karin
Published in : Journal of Analytical Atomic Spectrometry
Volume(Issue) : 27
Issue : 7
Pages : 1120
Pages to: 1130
Publisher / Ed. Institution : Royal Society of Chemistry
Publisher / Ed. Institution: London
Issue Date: 2012
Language : Englisch / English
Subjects : Particle-membrane interaction; Engineered nanoparticles; ICPMS; Field flow fractionation
Subject (DDC) : 620: Ingenieurwesen
Abstract: The analysis of engineered nanomaterials (ENMs), especially nanoparticles (ENPs) is a fast growing analytical research field. New trends in plasma spectrometry such as direct single particle inductively coupled plasma mass spectrometry (spICPMS) or the coupling of asymmetric flow field flow fractionation to ICPMS (A4F-ICPMS) allow direct analysis of ENPs by getting not only chemical but also size information simultaneously. However, in both techniques dilution of ENP samples is needed or occurs during analysis. The colloidal stability and the agglomeration behavior depend on the ENP-type, coating agent and also on the surrounding media. The stability of charge stabilized ENPs is especially sensitive to changes of pH or ionic strength, sometimes even to dilution. Although the stability of sterically stabilized ENP is typically less affected by the above mentioned factors, agglomeration can still occur in certain environments. Thus, storage, handling and sample preparation is a big challenge in ENP analysis. Kinetic studies of different ENPs, representative for typical nanoparticle types and coatings, point out that the behavior is dependent on various influencing factors pertaining to the chemical environment (pH, ionic strength, dilution). In this study polyvinyl alcohol (Ag@PVA) and citrate (Ag@citrate) stabilized silver nanoparticles, as well as titanium oxide ENPs coated with poly-acrylate (TiO2@PA) have been studied. A simple analytical approach using batch analysis with dynamic light scattering (DLS) is proposed for a fast assessment of samples containing unknown ENP types or structures. Furthermore, unwanted particle-membrane-interactions, which often lead to inappropriate recovery rates in A4F fractionation, are investigated. They are caused by the electrostatic charges carried by different membrane materials and the resulting interaction with the ENP charge. This is critically discussed for membrane materials typical for A4F analysis: polyethersulfone (PES), regenerated cellulose (RC), and polyvinylidene difluoride (PVDF).
Departement: Life Sciences und Facility Management
Organisational Unit: Institut für Chemie und Biotechnologie (ICBT)
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
Type of review: Peer review (Publikation)
DOI : 10.1039/C2JA30024A
ISSN: 0267-9477
URI: https://digitalcollection.zhaw.ch/handle/11475/2076
License (according to publishing contract) : Lizenz gemäss Verlagsvertrag / Licence according to publishing contract
Appears in Collections:Publikationen Life Sciences und Facility Management

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