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dc.contributor.authorSchroeder, Clemens-
dc.contributor.authorPark, Min Tae M.-
dc.contributor.authorGermann, Jürgen-
dc.contributor.authorChakravarty, M. Mallar-
dc.contributor.authorMichels, Lars-
dc.contributor.authorKollias, Spyros-
dc.contributor.authorKroll, Sara L.-
dc.contributor.authorBuck, Alfred-
dc.contributor.authorTreyer, Valerie-
dc.contributor.authorSavaskan, Egemen-
dc.contributor.authorUnschuld, Paul G.-
dc.contributor.authorNitsch, Roger M.-
dc.contributor.authorKälin, Andrea M.-
dc.contributor.authorHock, Christoph-
dc.contributor.authorGietl, Anton F.-
dc.contributor.authorLeh, Sandra E.-
dc.date.accessioned2020-10-22T11:54:49Z-
dc.date.available2020-10-22T11:54:49Z-
dc.date.issued2017-05-
dc.identifier.issn0953-816Xde_CH
dc.identifier.issn1460-9568de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/20701-
dc.description.abstractAβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11-C-Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P < 0.05, FDR corrected), whereas volumes of the hippocampi and their subregions were not associated with cortical or regional PiB uptake (all P > 0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P < 0.05, FDR corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofEuropean Journal of Neurosciencede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAlzheimer's diseasede_CH
dc.subjectBeta-amyloidde_CH
dc.subjectHippocampal shapede_CH
dc.subjectMagnetic resonance imagingde_CH
dc.subjectPositron emission tomographyde_CH
dc.subjectAgedde_CH
dc.subjectAmyloid beta-Peptidede_CH
dc.subjectHippocampusde_CH
dc.subjectHumande_CH
dc.subjectRadiopharmaceuticalsde_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titleHippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individualsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementFinanzen & Servicesde_CH
dc.identifier.doi10.1111/ejn.13408de_CH
dc.identifier.pmid27646656de_CH
zhaw.funding.euNode_CH
zhaw.issue10de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end1251de_CH
zhaw.pages.start1241de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume45de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedAngewandte Gerontologiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Schroeder, C., Park, M. T. M., Germann, J., Chakravarty, M. M., Michels, L., Kollias, S., Kroll, S. L., Buck, A., Treyer, V., Savaskan, E., Unschuld, P. G., Nitsch, R. M., Kälin, A. M., Hock, C., Gietl, A. F., & Leh, S. E. (2017). Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals. European Journal of Neuroscience, 45(10), 1241–1251. https://doi.org/10.1111/ejn.13408
Schroeder, C. et al. (2017) ‘Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals’, European Journal of Neuroscience, 45(10), pp. 1241–1251. Available at: https://doi.org/10.1111/ejn.13408.
C. Schroeder et al., “Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals,” European Journal of Neuroscience, vol. 45, no. 10, pp. 1241–1251, May 2017, doi: 10.1111/ejn.13408.
SCHROEDER, Clemens, Min Tae M. PARK, Jürgen GERMANN, M. Mallar CHAKRAVARTY, Lars MICHELS, Spyros KOLLIAS, Sara L. KROLL, Alfred BUCK, Valerie TREYER, Egemen SAVASKAN, Paul G. UNSCHULD, Roger M. NITSCH, Andrea M. KÄLIN, Christoph HOCK, Anton F. GIETL und Sandra E. LEH, 2017. Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals. European Journal of Neuroscience. Mai 2017. Bd. 45, Nr. 10, S. 1241–1251. DOI 10.1111/ejn.13408
Schroeder, Clemens, Min Tae M. Park, Jürgen Germann, M. Mallar Chakravarty, Lars Michels, Spyros Kollias, Sara L. Kroll, et al. 2017. “Hippocampal Shape Alterations Are Associated with Regional Aβ Load in Cognitively Normal Elderly Individuals.” European Journal of Neuroscience 45 (10): 1241–51. https://doi.org/10.1111/ejn.13408.
Schroeder, Clemens, et al. “Hippocampal Shape Alterations Are Associated with Regional Aβ Load in Cognitively Normal Elderly Individuals.” European Journal of Neuroscience, vol. 45, no. 10, May 2017, pp. 1241–51, https://doi.org/10.1111/ejn.13408.


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