| Publikationstyp: | Konferenz: Poster |
| Art der Begutachtung: | Peer review (Abstract) |
| Titel: | Photostability of sennosides in solution and their degradation products 1 |
| Autor/-in: | Meier, Nadja Meier, Beat Peter, Samuel Josic, Goijko Wolfram, Evelyn |
| DOI: | 10.1055/s-0037-1608273 |
| Erschienen in: | Planta Medica International Open |
| Band(Heft): | 4 |
| Angaben zur Konferenz: | 65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), Basel, 3-6 September 2017 |
| Erscheinungsdatum: | 24-Okt-2017 |
| Verlag / Hrsg. Institution: | Thieme |
| ISSN: | 2509-6656 2509-9264 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik 660.6: Biotechnologie |
| Zusammenfassung: | The leaves and pods of Alexandrian and Tinnevelly senna were used for centuries as laxatives. Their main active constituents are the dianthron glucosides (sennoside A – D and A1) and anthraquinone glucosides [1]. The photochemical instability of sennoside A was published in 1980 [2]. The authors postulated a degradation to rhein. However, the degradation products were not well examined and only one solvent was used in the study. The aim was to test the photostability of sennosides A, B and C in different solvents, to detect the degradation products as well as to examine if and when the aglycones aloe-emodin and rhein are formed. Sennosides were dissolved in different solvents and exposed to light (Fluora® growth lamps), samples were taken over a period of 14 days to 1 month and analysed by UHPLC-PDA/QDa. After 18h of light exposure 50 – 60% of the sennosides degraded in a solution with methanol/0.1% sodium bicarbonate (70:30 v/v) into other sennosides and rhein-8-glucoside. The effect is less distinct in solution of 0.1%sodium bicarbonatewith a degradation of ˜10% and did not occur with storage at room temperature and 4 °C while protected from light. Also, further degradation was stopped without light exposure. A formation of the aglycones aloe-emodin or rhein was not measured at any time, in contrary, in a senna extract exposed to light rhein degraded as well. [1] Hänsel, R. & Sticher, O. Pharmakognosie – Phytopharmazie 9th edition. Springer Medizin Verlag Heidelberg; 2010 [2] Nabil Aboul-Enein M, Wasser G.M, El-Difrawy S.M. Fitoterapia 1980; 51: 157 – 159. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/1962 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Meier, N., Meier, B., Peter, S., Josic, G., & Wolfram, E. (2017). Photostability of sennosides in solution and their degradation products 1 [Conference poster]. Planta Medica International Open, 4. https://doi.org/10.1055/s-0037-1608273
Meier, N. et al. (2017) ‘Photostability of sennosides in solution and their degradation products 1’, in Planta Medica International Open. Thieme. Available at: https://doi.org/10.1055/s-0037-1608273.
N. Meier, B. Meier, S. Peter, G. Josic, and E. Wolfram, “Photostability of sennosides in solution and their degradation products 1,” in Planta Medica International Open, Oct. 2017, vol. 4. doi: 10.1055/s-0037-1608273.
MEIER, Nadja, Beat MEIER, Samuel PETER, Goijko JOSIC und Evelyn WOLFRAM, 2017. Photostability of sennosides in solution and their degradation products 1. In: Planta Medica International Open. Conference poster. Thieme. 24 Oktober 2017
Meier, Nadja, Beat Meier, Samuel Peter, Goijko Josic, and Evelyn Wolfram. 2017. “Photostability of Sennosides in Solution and Their Degradation Products 1.” Conference poster. In Planta Medica International Open. Vol. 4. Thieme. https://doi.org/10.1055/s-0037-1608273.
Meier, Nadja, et al. “Photostability of Sennosides in Solution and Their Degradation Products 1.” Planta Medica International Open, vol. 4, Thieme, 2017, https://doi.org/10.1055/s-0037-1608273.
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