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dc.contributor.authorTrifan, Adriana-
dc.contributor.authorOpitz, Sebastian-
dc.contributor.authorJosuran, Roland-
dc.contributor.authorGrubelnik, Andreas-
dc.contributor.authorEsslinger, Nils-
dc.contributor.authorPeter, Samuel-
dc.contributor.authorBräm, Sarah-
dc.contributor.authorMeier, Nadja-
dc.contributor.authorWolfram, Evelyn-
dc.date.accessioned2018-01-09T15:30:53Z-
dc.date.available2018-01-09T15:30:53Z-
dc.date.issued2017-12-27-
dc.identifier.issn0278-6915de_CH
dc.identifier.issn1873-6351de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/1958-
dc.description.abstractComfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti-inflammatory properties. Up to date, key activity-determining constituents of comfrey root extracts have not been completely elucidated. Therefore, we applied different approaches to further characterize a comfrey root extract (65% ethanol). The phenolic profile of comfrey root sample was characterized by HPLC-DAD-QTOF-MS/MS. Rosmarinic acid was identified as main phenolic constituent (7.55 mg/g extract). Moreover, trimers and tetramers of caffeic acid (isomers of salvianolic acid A, B and C) were identified and quantified for the first time in comfrey root. In addition, pyrrolizidine alkaloids were evaluated by HPLC-QQQ-MS/MS and acetylintermedine, acetyllycopsamine and their N-oxides were determined as major pyrrolizidine alkaloids in the comfrey root sample. Lastly, the antioxidant activity was determined using four assays: DPPH and ABTS radicals scavenging assays, reducing power assay and 15-lipoxygenase inhibition assay. Comfrey root extract exhibited significant antioxidant activities when compared to known antioxidants. Thus, comfrey root is an important source of phenolic compounds endowed with antioxidant activity which may contribute to the overall bioactivity of Symphytum preparations.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofFood and Chemical Toxicologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAntioxidant activityde_CH
dc.subjectPhenolic compoundde_CH
dc.subjectPyrrolizidine alkaloidde_CH
dc.subjectSalvianolic acidde_CH
dc.subjectSymphytum officinale L.de_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc580: Pflanzen (Botanik)de_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleIs comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) rootsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.fct.2017.12.051de_CH
dc.identifier.pmid29288756de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end187de_CH
zhaw.pages.start178de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume112de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPflanzenverwendungde_CH
zhaw.webfeedPhytopharmaziede_CH
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Trifan, A., Opitz, S., Josuran, R., Grubelnik, A., Esslinger, N., Peter, S., Bräm, S., Meier, N., & Wolfram, E. (2017). Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots. Food and Chemical Toxicology, 112, 178–187. https://doi.org/10.1016/j.fct.2017.12.051
Trifan, A. et al. (2017) ‘Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots’, Food and Chemical Toxicology, 112, pp. 178–187. Available at: https://doi.org/10.1016/j.fct.2017.12.051.
A. Trifan et al., “Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots,” Food and Chemical Toxicology, vol. 112, pp. 178–187, Dec. 2017, doi: 10.1016/j.fct.2017.12.051.
TRIFAN, Adriana, Sebastian OPITZ, Roland JOSURAN, Andreas GRUBELNIK, Nils ESSLINGER, Samuel PETER, Sarah BRÄM, Nadja MEIER und Evelyn WOLFRAM, 2017. Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots. Food and Chemical Toxicology. 27 Dezember 2017. Bd. 112, S. 178–187. DOI 10.1016/j.fct.2017.12.051
Trifan, Adriana, Sebastian Opitz, Roland Josuran, Andreas Grubelnik, Nils Esslinger, Samuel Peter, Sarah Bräm, Nadja Meier, and Evelyn Wolfram. 2017. “Is Comfrey Root More than Toxic Pyrrolizidine Alkaloids? Salvianolic Acids among Antioxidant Polyphenols in Comfrey (Symphytum Officinale L.) Roots.” Food and Chemical Toxicology 112 (December): 178–87. https://doi.org/10.1016/j.fct.2017.12.051.
Trifan, Adriana, et al. “Is Comfrey Root More than Toxic Pyrrolizidine Alkaloids? Salvianolic Acids among Antioxidant Polyphenols in Comfrey (Symphytum Officinale L.) Roots.” Food and Chemical Toxicology, vol. 112, Dec. 2017, pp. 178–87, https://doi.org/10.1016/j.fct.2017.12.051.


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