| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots |
| Autor/-in: | Trifan, Adriana Opitz, Sebastian Josuran, Roland Grubelnik, Andreas Esslinger, Nils Peter, Samuel Bräm, Sarah Meier, Nadja Wolfram, Evelyn |
| DOI: | 10.1016/j.fct.2017.12.051 |
| Erschienen in: | Food and Chemical Toxicology |
| Band(Heft): | 112 |
| Seite(n): | 178 |
| Seiten bis: | 187 |
| Erscheinungsdatum: | 27-Dez-2017 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 0278-6915 1873-6351 |
| Sprache: | Englisch |
| Schlagwörter: | Antioxidant activity; Phenolic compound; Pyrrolizidine alkaloid; Salvianolic acid; Symphytum officinale L. |
| Fachgebiet (DDC): | 572: Biochemie 580: Pflanzen (Botanik) 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | Comfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti-inflammatory properties. Up to date, key activity-determining constituents of comfrey root extracts have not been completely elucidated. Therefore, we applied different approaches to further characterize a comfrey root extract (65% ethanol). The phenolic profile of comfrey root sample was characterized by HPLC-DAD-QTOF-MS/MS. Rosmarinic acid was identified as main phenolic constituent (7.55 mg/g extract). Moreover, trimers and tetramers of caffeic acid (isomers of salvianolic acid A, B and C) were identified and quantified for the first time in comfrey root. In addition, pyrrolizidine alkaloids were evaluated by HPLC-QQQ-MS/MS and acetylintermedine, acetyllycopsamine and their N-oxides were determined as major pyrrolizidine alkaloids in the comfrey root sample. Lastly, the antioxidant activity was determined using four assays: DPPH and ABTS radicals scavenging assays, reducing power assay and 15-lipoxygenase inhibition assay. Comfrey root extract exhibited significant antioxidant activities when compared to known antioxidants. Thus, comfrey root is an important source of phenolic compounds endowed with antioxidant activity which may contribute to the overall bioactivity of Symphytum preparations. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/1958 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Trifan, A., Opitz, S., Josuran, R., Grubelnik, A., Esslinger, N., Peter, S., Bräm, S., Meier, N., & Wolfram, E. (2017). Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots. Food and Chemical Toxicology, 112, 178–187. https://doi.org/10.1016/j.fct.2017.12.051
Trifan, A. et al. (2017) ‘Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots’, Food and Chemical Toxicology, 112, pp. 178–187. Available at: https://doi.org/10.1016/j.fct.2017.12.051.
A. Trifan et al., “Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots,” Food and Chemical Toxicology, vol. 112, pp. 178–187, Dec. 2017, doi: 10.1016/j.fct.2017.12.051.
TRIFAN, Adriana, Sebastian OPITZ, Roland JOSURAN, Andreas GRUBELNIK, Nils ESSLINGER, Samuel PETER, Sarah BRÄM, Nadja MEIER und Evelyn WOLFRAM, 2017. Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots. Food and Chemical Toxicology. 27 Dezember 2017. Bd. 112, S. 178–187. DOI 10.1016/j.fct.2017.12.051
Trifan, Adriana, Sebastian Opitz, Roland Josuran, Andreas Grubelnik, Nils Esslinger, Samuel Peter, Sarah Bräm, Nadja Meier, and Evelyn Wolfram. 2017. “Is Comfrey Root More than Toxic Pyrrolizidine Alkaloids? Salvianolic Acids among Antioxidant Polyphenols in Comfrey (Symphytum Officinale L.) Roots.” Food and Chemical Toxicology 112 (December): 178–87. https://doi.org/10.1016/j.fct.2017.12.051.
Trifan, Adriana, et al. “Is Comfrey Root More than Toxic Pyrrolizidine Alkaloids? Salvianolic Acids among Antioxidant Polyphenols in Comfrey (Symphytum Officinale L.) Roots.” Food and Chemical Toxicology, vol. 112, Dec. 2017, pp. 178–87, https://doi.org/10.1016/j.fct.2017.12.051.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.