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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-19485
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dc.contributor.authorKhojasteh, Abbas-
dc.contributor.authorMetón, Isidoro-
dc.contributor.authorCamino, Sergio-
dc.contributor.authorCusido, Rosa M.-
dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorPalazon, Javier-
dc.date.accessioned2020-02-19T14:33:58Z-
dc.date.available2020-02-19T14:33:58Z-
dc.date.issued2019-
dc.identifier.issn1422-0067de_CH
dc.identifier.issn1661-6596de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/19485-
dc.description.abstractMany medicinal plant species are currently threatened in their natural habitats because of the growing demand for phytochemicals worldwide. A sustainable alternative for the production of bioactive plant compounds are plant biofactories based on cell cultures and organs. In addition, plant extracts from biofactories have significant advantages over those obtained from plants, since they are free of contamination by microorganisms, herbicides and pesticides, and they provide more stable levels of active ingredients. In this context, we report the establishment of Satureja khuzistanica cell cultures able to produce high amounts of rosmarinic acid (RA). The production of this phytopharmaceutical was increased when the cultures were elicited with coronatine and scaled up to a benchtop bioreactor. S. khuzistanica extracts enriched in RA were found to reduce the viability of cancer cell lines, increasing the sub-G0/G1 cell population and the activity of caspase-8 in MCF-7 cells, which suggest that S. khuzistanica extracts can induce apoptosis of MCF-7 cells through activation of the extrinsic pathway. In addition, our findings indicate that other compounds in S. khuzistanica extracts may act synergistically to potentiate the anticancer activity of RA.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofInternational Journal of Molecular Sciencesde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectHepG2 human hepatoma cellde_CH
dc.subjectMCF-7 human breast adenocarcinoma cellde_CH
dc.subjectSatureja khuzistanicade_CH
dc.subjectCoronatinede_CH
dc.subjectPlant cell culturede_CH
dc.subjectRosmarinic acidde_CH
dc.subjectAdenocarcinomade_CH
dc.subjectAziridinede_CH
dc.subjectBioreactorde_CH
dc.subjectCaspase 8de_CH
dc.subjectCaspasesde_CH
dc.subjectCell culture techniquede_CH
dc.subjectCell cycle checkpointde_CH
dc.subjectCell linede_CH
dc.subjectCell survivalde_CH
dc.subjectCinnamatede_CH
dc.subjectCyclohexenesde_CH
dc.subjectDepsidede_CH
dc.subjectHep G2 cellde_CH
dc.subjectHumande_CH
dc.subjectMCF-7 cellde_CH
dc.subjectPhytochemicalde_CH
dc.subjectPlant extractde_CH
dc.subjectMedicinal plantsde_CH
dc.subjectEndangered speciede_CH
dc.subjectTumorde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleIn vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanicade_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.3390/ijms20102400de_CH
dc.identifier.doi10.21256/zhaw-19485-
dc.identifier.pmid31096565de_CH
zhaw.funding.euNode_CH
zhaw.issue10de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start2400de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume20de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
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Khojasteh, A., Metón, I., Camino, S., Cusido, R. M., Eibl-Schindler, R., & Palazon, J. (2019). In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica. International Journal of Molecular Sciences, 20(10), 2400. https://doi.org/10.3390/ijms20102400
Khojasteh, A. et al. (2019) ‘In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica’, International Journal of Molecular Sciences, 20(10), p. 2400. Available at: https://doi.org/10.3390/ijms20102400.
A. Khojasteh, I. Metón, S. Camino, R. M. Cusido, R. Eibl-Schindler, and J. Palazon, “In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica,” International Journal of Molecular Sciences, vol. 20, no. 10, p. 2400, 2019, doi: 10.3390/ijms20102400.
KHOJASTEH, Abbas, Isidoro METÓN, Sergio CAMINO, Rosa M. CUSIDO, Regine EIBL-SCHINDLER und Javier PALAZON, 2019. In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica. International Journal of Molecular Sciences. 2019. Bd. 20, Nr. 10, S. 2400. DOI 10.3390/ijms20102400
Khojasteh, Abbas, Isidoro Metón, Sergio Camino, Rosa M. Cusido, Regine Eibl-Schindler, and Javier Palazon. 2019. “In Vitro Study of the Anticancer Effects of Biotechnological Extracts of the Endangered Plant Species Satureja Khuzistanica.” International Journal of Molecular Sciences 20 (10): 2400. https://doi.org/10.3390/ijms20102400.
Khojasteh, Abbas, et al. “In Vitro Study of the Anticancer Effects of Biotechnological Extracts of the Endangered Plant Species Satureja Khuzistanica.” International Journal of Molecular Sciences, vol. 20, no. 10, 2019, p. 2400, https://doi.org/10.3390/ijms20102400.


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