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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica
Authors: Khojasteh, Abbas
Metón, Isidoro
Camino, Sergio
Cusido, Rosa M.
Eibl-Schindler, Regine
Palazon, Javier
et. al: No
DOI: 10.3390/ijms20102400
Published in: International Journal of Molecular Sciences
Volume(Issue): 20
Issue: 10
Pages: 2400
Issue Date: 2019
Publisher / Ed. Institution: MDPI
ISSN: 1422-0067
Language: English
Subjects: HepG2 human hepatoma cell; MCF-7 human breast adenocarcinoma cell; Satureja khuzistanica; Coronatine; Plant cell culture; Rosmarinic acid; Adenocarcinoma; Aziridine; Bioreactor; Caspase 8; Caspases; Cell culture technique; Cell cycle checkpoint; Cell line; Cell survival; Cinnamate; Cyclohexenes; Depside; Hep G2 cell; Human; MCF-7 cell; Phytochemical; Plant extract; Medicinal plants; Endangered specie; Tumor
Subject (DDC): 660: Chemical engineering
Abstract: Many medicinal plant species are currently threatened in their natural habitats because of the growing demand for phytochemicals worldwide. A sustainable alternative for the production of bioactive plant compounds are plant biofactories based on cell cultures and organs. In addition, plant extracts from biofactories have significant advantages over those obtained from plants, since they are free of contamination by microorganisms, herbicides and pesticides, and they provide more stable levels of active ingredients. In this context, we report the establishment of Satureja khuzistanica cell cultures able to produce high amounts of rosmarinic acid (RA). The production of this phytopharmaceutical was increased when the cultures were elicited with coronatine and scaled up to a benchtop bioreactor. S. khuzistanica extracts enriched in RA were found to reduce the viability of cancer cell lines, increasing the sub-G0/G1 cell population and the activity of caspase-8 in MCF-7 cells, which suggest that S. khuzistanica extracts can induce apoptosis of MCF-7 cells through activation of the extrinsic pathway. In addition, our findings indicate that other compounds in S. khuzistanica extracts may act synergistically to potentiate the anticancer activity of RA.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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