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Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Peer review (Publikation)
Titel: Inhibitory antibodies designed for matrix metalloproteinase modulation
Autor/-in: Fischer, Thomas
Riedl, Rainer
et. al: No
DOI: 10.3390/molecules24122265
10.21256/zhaw-19484
Erschienen in: Molecules
Band(Heft): 24
Heft: 12
Seiten: 2265
Erscheinungsdatum: 2019
Verlag / Hrsg. Institution: MDPI
ISSN: 1420-3049
1433-1373
Sprache: Englisch
Schlagwörter: Drug design; Inhibitory antibody; Matrix metalloproteinase; Selectivity; Tissue inhibitors of metalloproteinase; Amino acid sequence; Animal; Monoclonal antibody; Binding site; Human; Matrix metalloproteinase inhibitors; Molecular conformation; Molecular docking simulation; Molecular dynamics simulation; Protein binding; Structure-activity relationship
Fachgebiet (DDC): 571: Physiologie und verwandte Themen
Zusammenfassung: The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis. Modulation of the target class with small molecule drugs has not led to the anticipated success until present, as all clinical trials failed due to unacceptable side effects or a lack of therapeutic outcome. Monoclonal antibodies offer a tremendous therapeutic potential given their high target selectivity and good pharmacokinetic profiles. For the treatment of a variety of diseases there are already antibody therapies available and the number is increasing. Recently, several antibodies were developed for the selective inhibition of single MMPs that showed high potency and were therefore investigated in in vivo studies with promising results. In this review, we highlight the progress that has been achieved toward the design of inhibitory antibodies that successfully modulate MMP-9 and MMP-14.
URI: https://digitalcollection.zhaw.ch/handle/11475/19484
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): CC BY 4.0: Namensnennung 4.0 International
Departement: Life Sciences und Facility Management
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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