Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-19319
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dc.contributor.authorSchirmer, Cedric-
dc.contributor.authorNussbaumer, Thomas-
dc.contributor.authorSchöb, Reto-
dc.contributor.authorPörtner, Ralf-
dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorEibl, Dieter-
dc.date.accessioned2020-01-30T13:19:16Z-
dc.date.available2020-01-30T13:19:16Z-
dc.date.issued2018-
dc.identifier.isbn978-1-78923-718-4de_CH
dc.identifier.isbn978-1-78923-719-1de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/19319-
dc.description.abstractStirred tank bioreactors are still the predominant cultivation systems in large scale biopharmaceutical production. Today, several manufacturers provide both reusable and single-use systems, whereas the broad variety of designs and properties lead to deviations in biological performance. Although the methods for bioreactor characterization are well established, varying experimental conditions and procedures can result in significantly different outcomes. In order to guarantee a reliable comparison and evaluation of different single-use and reusable bioreactor types, standardized methods for their characterization are needed. Equally important is the biological capability of bioreactors, which must be accessed by standardized cultivation procedures of industrially relevant organisms (bacteria, yeasts as well as mammalian and animal cell cultures). In addition, the implementation of well-defined uniform procedures for biological and engineering characterization during the development phase can support a fast assessment of the suitability of a bioreactor system. Based on stirred bioreactors, we describe the aspects of the engineering characterization in order to discuss further the biological characterization as a valuable complement. Finally, a case study is presented.de_CH
dc.language.isoende_CH
dc.publisherIntechOpende_CH
dc.relation.ispartofBiopharmaceuticalsde_CH
dc.rightshttp://creativecommons.org/licenses/by/3.0/de_CH
dc.subjectStirred bioreactorde_CH
dc.subjectCharacterizationde_CH
dc.subjectMixing timede_CH
dc.subjectPower inputde_CH
dc.subjectVolumetric mass transfer coefficientde_CH
dc.subjectDevelopmentde_CH
dc.subjectCultivation systemde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleDevelopment, engineering and biological characterization of stirred tank bioreactorsde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeLondonde_CH
dc.identifier.doi10.5772/intechopen.79444de_CH
dc.identifier.doi10.21256/zhaw-19319-
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end107de_CH
zhaw.pages.start87de_CH
zhaw.parentwork.editorYeh, Ming-Kung-
zhaw.parentwork.editorChen, Yuan-Chuan-
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewEditorial reviewde_CH
zhaw.webfeedVerfahrenstechnikde_CH
zhaw.author.additionalNode_CH
Appears in Collections:Publikationen Life Sciences und Facility Management



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