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Publikationstyp: Buchbeitrag
Art der Begutachtung: Editorial review
Titel: Development, engineering and biological characterization of stirred tank bioreactors
Autor/-in: Schirmer, Cedric
Nussbaumer, Thomas
Schöb, Reto
Pörtner, Ralf
Eibl-Schindler, Regine
Eibl, Dieter
et. al: No
DOI: 10.5772/intechopen.79444
10.21256/zhaw-19319
Erschienen in: Biopharmaceuticals
Herausgeber/-in des übergeordneten Werkes: Yeh, Ming-Kung
Chen, Yuan-Chuan
Seiten: 87
Seiten bis: 107
Erscheinungsdatum: 2018
Verlag / Hrsg. Institution: IntechOpen
Verlag / Hrsg. Institution: London
ISBN: 978-1-78923-718-4
978-1-78923-719-1
Sprache: Englisch
Schlagwörter: Stirred bioreactor; Characterization; Mixing time; Power input; Volumetric mass transfer coefficient; Development; Cultivation system
Fachgebiet (DDC): 660: Technische Chemie
Zusammenfassung: Stirred tank bioreactors are still the predominant cultivation systems in large scale biopharmaceutical production. Today, several manufacturers provide both reusable and single-use systems, whereas the broad variety of designs and properties lead to deviations in biological performance. Although the methods for bioreactor characterization are well established, varying experimental conditions and procedures can result in significantly different outcomes. In order to guarantee a reliable comparison and evaluation of different single-use and reusable bioreactor types, standardized methods for their characterization are needed. Equally important is the biological capability of bioreactors, which must be accessed by standardized cultivation procedures of industrially relevant organisms (bacteria, yeasts as well as mammalian and animal cell cultures). In addition, the implementation of well-defined uniform procedures for biological and engineering characterization during the development phase can support a fast assessment of the suitability of a bioreactor system. Based on stirred bioreactors, we describe the aspects of the engineering characterization in order to discuss further the biological characterization as a valuable complement. Finally, a case study is presented.
URI: https://digitalcollection.zhaw.ch/handle/11475/19319
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): CC BY 3.0: Namensnennung 3.0 Unported
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Chemie und Biotechnologie (ICBT)
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management



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