Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-19319
Publication type: Book part
Type of review: Editorial review
Title: Development, engineering and biological characterization of stirred tank bioreactors
Authors: Schirmer, Cedric
Nussbaumer, Thomas
Schöb, Reto
Pörtner, Ralf
Eibl-Schindler, Regine
Eibl, Dieter
et. al: No
DOI: 10.5772/intechopen.79444
10.21256/zhaw-19319
Published in: Biopharmaceuticals
Editors of the parent work: Yeh, Ming-Kung
Chen, Yuan-Chuan
Pages: 87
Pages to: 107
Issue Date: 2018
Publisher / Ed. Institution: IntechOpen
Publisher / Ed. Institution: London
ISBN: 978-1-78923-718-4
978-1-78923-719-1
Language: English
Subjects: Stirred bioreactor; Characterization; Mixing time; Power input; Volumetric mass transfer coefficient; Development; Cultivation system
Subject (DDC): 660: Chemical engineering
Abstract: Stirred tank bioreactors are still the predominant cultivation systems in large scale biopharmaceutical production. Today, several manufacturers provide both reusable and single-use systems, whereas the broad variety of designs and properties lead to deviations in biological performance. Although the methods for bioreactor characterization are well established, varying experimental conditions and procedures can result in significantly different outcomes. In order to guarantee a reliable comparison and evaluation of different single-use and reusable bioreactor types, standardized methods for their characterization are needed. Equally important is the biological capability of bioreactors, which must be accessed by standardized cultivation procedures of industrially relevant organisms (bacteria, yeasts as well as mammalian and animal cell cultures). In addition, the implementation of well-defined uniform procedures for biological and engineering characterization during the development phase can support a fast assessment of the suitability of a bioreactor system. Based on stirred bioreactors, we describe the aspects of the engineering characterization in order to discuss further the biological characterization as a valuable complement. Finally, a case study is presented.
URI: https://digitalcollection.zhaw.ch/handle/11475/19319
Fulltext version: Published version
License (according to publishing contract): CC BY 3.0: Attribution 3.0 Unported
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in Collections:Publikationen Life Sciences und Facility Management



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