| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases |
| Authors: | Voss, Moritz Honda Malca, Sumire Buller, Rebecca |
| et. al: | No |
| DOI: | 10.1002/chem.201905752 |
| Published in: | Chemistry - A European Journal |
| Issue Date: | 22-Jan-2020 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 0947-6539 1521-3765 |
| Language: | English |
| Subjects: | C-H activation; Fe/ αKG-dependent Halogenases; Biocatalysis; Enzyme Engineering; Genome Mining |
| Subject (DDC): | 660.6: Biotechnology |
| Abstract: | Freestanding non-heme iron halogenases are α-ketoglutarate dependent oxidoreductases that catalyze the installation of halogen atoms into unactivated sp 3 -hybridized carbon centers with high stereo- and regioselectivity. Since their discovery in 2014, a small number of indole-alkaloid and amino acid halogenases have been identified and characterized. First enzyme engineering examples suggest that the accessible substrate range of these enzymes may be expanded through the use of rational enzyme design and directed evolution. Structural investigations of non-heme iron halogenases acting of freestanding as well as tethered substrate are beginning to inform about the principles of the underlying halogenation mechanism. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/19230 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Voss, M., Honda Malca, S., & Buller, R. (2020). Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases. Chemistry - A European Journal. https://doi.org/10.1002/chem.201905752
Voss, M., Honda Malca, S. and Buller, R. (2020) ‘Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases’, Chemistry - A European Journal [Preprint]. Available at: https://doi.org/10.1002/chem.201905752.
M. Voss, S. Honda Malca, and R. Buller, “Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases,” Chemistry - A European Journal, Jan. 2020, doi: 10.1002/chem.201905752.
VOSS, Moritz, Sumire HONDA MALCA und Rebecca BULLER, 2020. Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases. Chemistry - A European Journal. 22 Januar 2020. DOI 10.1002/chem.201905752
Voss, Moritz, Sumire Honda Malca, and Rebecca Buller. 2020. “Exploring the Biocatalytic Potential of Fe/α‐Ketoglutarate Dependent Halogenases.” Chemistry - A European Journal, January. https://doi.org/10.1002/chem.201905752.
Voss, Moritz, et al. “Exploring the Biocatalytic Potential of Fe/α‐Ketoglutarate Dependent Halogenases.” Chemistry - A European Journal, Jan. 2020, https://doi.org/10.1002/chem.201905752.
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