Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases
Authors: Voss, Moritz
Honda Malca, Sumire
Buller, Rebecca
et. al: No
DOI: 10.1002/chem.201905752
Published in: Chemistry - A European Journal
Issue Date: 22-Jan-2020
Publisher / Ed. Institution: Wiley
ISSN: 0947-6539
Language: English
Subjects: C-H activation; Fe/ αKG-dependent Halogenases; Biocatalysis; Enzyme Engineering; Genome Mining
Subject (DDC): 660.6: Biotechnology
Abstract: Freestanding non-heme iron halogenases are α-ketoglutarate dependent oxidoreductases that catalyze the installation of halogen atoms into unactivated sp 3 -hybridized carbon centers with high stereo- and regioselectivity. Since their discovery in 2014, a small number of indole-alkaloid and amino acid halogenases have been identified and characterized. First enzyme engineering examples suggest that the accessible substrate range of these enzymes may be expanded through the use of rational enzyme design and directed evolution. Structural investigations of non-heme iron halogenases acting of freestanding as well as tethered substrate are beginning to inform about the principles of the underlying halogenation mechanism.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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