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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Complete inclusion of bioactive molecules and particles in polydimethylsiloxane : a straightforward process under mild conditions
Authors: Faccio, Greta
Cont, Alice
Mailand, Erik
Zare-Eelanjegh, Elaheh
Innocenti Malini, Riccardo
Maniura-Weber, Katharina
Rossi, René M.
Spano, Fabrizio
et. al: No
DOI: 10.1038/s41598-019-54155-5
Published in: Scientific Reports
Volume(Issue): 9
Issue: 1
Pages: 17575
Issue Date: 2019
Publisher / Ed. Institution: Nature Publishing Group
ISSN: 2045-2322
Language: English
Subject (DDC): 572: Biochemistry
Abstract: By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and relative humidity, and is thus suitable for application to biological entities. Fluorescence and enzymatic activity measurements show that the biochemical properties of the proteins and enzyme tested are preserved, without loss due to adsorption at the liquid-polymer interface. Protected from external stimuli by the PDMS matrix, these soft liquid composite materials are new tools of interest for robotics, microfluidics, diagnostics and chemical microreactors.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: School of Engineering
Organisational Unit: Institute of Computational Physics (ICP)
Appears in Collections:Publikationen School of Engineering

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