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https://doi.org/10.21256/zhaw-18883| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application |
| Authors: | Büchler, Johannes Papadopoulou, Athena Buller, Rebecca |
| et. al: | No |
| DOI: | 10.3390/catal9121030 10.21256/zhaw-18883 |
| Published in: | Catalysts |
| Volume(Issue): | 9 |
| Issue: | 12 |
| Page(s): | 1030 |
| Issue Date: | Dec-2019 |
| Publisher / Ed. Institution: | MDPI |
| ISSN: | 2073-4344 |
| Language: | English |
| Subjects: | Flavin-dependent halogenase; Enzyme engineering; Anion promiscuity; Reaction engineering; Co-factor recycling; Biocatalysis |
| Subject (DDC): | 660.6: Biotechnology |
| Abstract: | The introduction of a halogen atom into a small molecule can effectively modulate its properties, yielding bioactive substances of agrochemical and pharmaceutical interest. Consequently, the development of selective halogenation strategies is of high technological value. Besides chemical methodologies, enzymatic halogenations have received increased interest as they allow the selective installation of halogen atoms in molecular scaffolds of varying complexity under mild reaction conditions. Today, a comprehensive library of aromatic halogenases exists, and enzyme as well as reaction engineering approaches are being explored to broaden this enzyme family’s biocatalytic application range. In this review, we highlight recent developments in the sourcing, engineering, and application of flavin-dependent halogenases with a special focus on chemoenzymatic and coupled biosynthetic approaches. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/18883 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| catalysts-09-01030.pdf | 1.95 MB | Adobe PDF |  View/Open |
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Büchler, J., Papadopoulou, A., & Buller, R. (2019). Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application. Catalysts, 9(12), 1030. https://doi.org/10.3390/catal9121030
Büchler, J., Papadopoulou, A. and Buller, R. (2019) ‘Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application’, Catalysts, 9(12), p. 1030. Available at: https://doi.org/10.3390/catal9121030.
J. Büchler, A. Papadopoulou, and R. Buller, “Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application,” Catalysts, vol. 9, no. 12, p. 1030, Dec. 2019, doi: 10.3390/catal9121030.
BÜCHLER, Johannes, Athena PAPADOPOULOU und Rebecca BULLER, 2019. Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application. Catalysts. Dezember 2019. Bd. 9, Nr. 12, S. 1030. DOI 10.3390/catal9121030
Büchler, Johannes, Athena Papadopoulou, and Rebecca Buller. 2019. “Recent Advances in Flavin-Dependent Halogenase Biocatalysis : Sourcing, Engineering, and Application.” Catalysts 9 (12): 1030. https://doi.org/10.3390/catal9121030.
Büchler, Johannes, et al. “Recent Advances in Flavin-Dependent Halogenase Biocatalysis : Sourcing, Engineering, and Application.” Catalysts, vol. 9, no. 12, Dec. 2019, p. 1030, https://doi.org/10.3390/catal9121030.
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