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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application
Authors : Büchler, Johannes
Papadopoulou, Athena
Buller, Rebecca
et. al : No
DOI : 10.3390/catal9121030
Published in : Catalysts
Volume(Issue) : 9
Issue : 12
Pages : 1030
Issue Date: Dec-2019
Publisher / Ed. Institution : MDPI
ISSN: 2073-4344
Language : English
Subjects : Flavin-dependent halogenase; Enzyme engineering; Anion promiscuity; Reaction engineering; Co-factor recycling; Biocatalysis
Subject (DDC) : 660.6: Biotechnology
Abstract: The introduction of a halogen atom into a small molecule can effectively modulate its properties, yielding bioactive substances of agrochemical and pharmaceutical interest. Consequently, the development of selective halogenation strategies is of high technological value. Besides chemical methodologies, enzymatic halogenations have received increased interest as they allow the selective installation of halogen atoms in molecular scaffolds of varying complexity under mild reaction conditions. Today, a comprehensive library of aromatic halogenases exists, and enzyme as well as reaction engineering approaches are being explored to broaden this enzyme family’s biocatalytic application range. In this review, we highlight recent developments in the sourcing, engineering, and application of flavin-dependent halogenases with a special focus on chemoenzymatic and coupled biosynthetic approaches.
Fulltext version : Published version
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in Collections:Publikationen Life Sciences und Facility Management

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