Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh

Trifan, Adriana; Vasincu, Alexandru; Luca, Simon Vlad; Neophytou, Christiana; Wolfram, Evelyn; Opitz, Sebastian; Sava, Daciana; Bucur, Laura; Cioroiu, Bogdan I.; Miron, Anca; Aprotosoaie, Ana Clara; Cioanca, Oana; Hancianu, Monica; Jitareanu, Alexandra; Constantinou, Andreas I.

doi:10.1016/j.fct.2019.110820

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh
Authors:	Trifan, Adriana Vasincu, Alexandru Luca, Simon Vlad Neophytou, Christiana Wolfram, Evelyn Opitz, Sebastian Sava, Daciana Bucur, Laura Cioroiu, Bogdan I. Miron, Anca Aprotosoaie, Ana Clara Cioanca, Oana Hancianu, Monica Jitareanu, Alexandra Constantinou, Andreas I.
et. al:	No
DOI:	10.1016/j.fct.2019.110820
Published in:	Food and Chemical Toxicology
Volume(Issue):	134
Issue:	110820
Issue Date:	2019
Publisher / Ed. Institution:	Elsevier
ISSN:	0278-6915 1873-6351
Language:	English
Subjects:	Anti-proliferative activity; Apoptosis; Phlorotannins; Brown algae
Subject (DDC):	572: Biochemistry
Abstract:	The Romanian coastlines of the Black Sea have abundant seaweed resources, but little effort has been done to investigate their biological potential. The aim of the present study was to assess the in vitro antioxidant and anti-proliferative effects of Cystoseira barbata (Stackhouse) C. Agardh (Sargassaceae), a brown alga inhabiting the Black Sea coast of Romania. The 70% acetone, methanol and water extracts of C. barbata were evaluated for their total phenolic content, antioxidant activity and anti-proliferative potential against human tumor cell lines (pulmonary A549, colon HT-29, mammary MCF-7) and the non-tumor mammary epithelial MCF-10A cell line. C. barbata 70% acetone extract (CBAE) displayed the highest antioxidant and cytotoxic activities. The mechanism of CBAE anti-proliferative activity involved initially increased intracellular ROS accumulation, followed by increased DNA content in the subG1 phase and DNA fragmentation leading to excessive apoptosis. Thus, our study provides a theoretical basis for the use of CBAE as a tumor preventive agent. Furthermore, UHPLC-DAD-QTOF-MS analysis of CBAE tentatively identified 18 phlorotannins as fucophlorethol and eckol derivatives, containing three up to seven phloroglucinol units. In conclusion, C. barbata represents a valuable source for the development of macroalgal-based products with putative use as nutraceuticals and pharmaceuticals.
URI:	https://digitalcollection.zhaw.ch/handle/11475/18869
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

There are no files associated with this item.

Show full item record

Trifan, A., Vasincu, A., Luca, S. V., Neophytou, C., Wolfram, E., Opitz, S., Sava, D., Bucur, L., Cioroiu, B. I., Miron, A., Aprotosoaie, A. C., Cioanca, O., Hancianu, M., Jitareanu, A., & Constantinou, A. I. (2019). Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh. Food and Chemical Toxicology, 134(110820). https://doi.org/10.1016/j.fct.2019.110820

Trifan, A. et al. (2019) ‘Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh’, Food and Chemical Toxicology, 134(110820). Available at: https://doi.org/10.1016/j.fct.2019.110820.

A. Trifan et al., “Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh,” Food and Chemical Toxicology, vol. 134, no. 110820, 2019, doi: 10.1016/j.fct.2019.110820.

TRIFAN, Adriana, Alexandru VASINCU, Simon Vlad LUCA, Christiana NEOPHYTOU, Evelyn WOLFRAM, Sebastian OPITZ, Daciana SAVA, Laura BUCUR, Bogdan I. CIOROIU, Anca MIRON, Ana Clara APROTOSOAIE, Oana CIOANCA, Monica HANCIANU, Alexandra JITAREANU und Andreas I. CONSTANTINOU, 2019. Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh. Food and Chemical Toxicology. 2019. Bd. 134, Nr. 110820. DOI 10.1016/j.fct.2019.110820

Trifan, Adriana, Alexandru Vasincu, Simon Vlad Luca, Christiana Neophytou, Evelyn Wolfram, Sebastian Opitz, Daciana Sava, et al. 2019. “Unravelling the Potential of Seaweeds from the Black Sea Coast of Romania as Bioactive Compounds Sources : Part I: Cystoseira Barbata (Stackhouse) C. Agardh.” Food and Chemical Toxicology 134 (110820). https://doi.org/10.1016/j.fct.2019.110820.

Trifan, Adriana, et al. “Unravelling the Potential of Seaweeds from the Black Sea Coast of Romania as Bioactive Compounds Sources : Part I: Cystoseira Barbata (Stackhouse) C. Agardh.” Food and Chemical Toxicology, vol. 134, no. 110820, 2019, https://doi.org/10.1016/j.fct.2019.110820.