Title: Alpha-1 antitrypsin deficiency : from the lung to the heart?
Authors : Curjuric, Ivan
Imboden, Medea
Bettschart, Robert
Caviezel, Seraina
Dratva, Julia
Pons, Marco
Rothe, Thomas
Schmidt-Trucksäss, Arno
Stolz, Daiana
Thun, Gian Andri
von Eckardstein, Arnold
Kronenberg, Florian
Ferrarotti, Ilaria
Probst-Hensch, Nicole M
et. al : No
Published in : Atherosclerosis
Volume(Issue) : 270
Pages : 166
Pages to: 172
Publisher / Ed. Institution : Elsevier
Issue Date: 2018
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (publication)
Language : English
Subjects : Alpha-1 antitrypsin deficiency; Cardiovascular disease; Cohort study; MESH): carotid intima-media thickness; Mendelian randomization analysis; Aged; Blood pressure; Carotid artery disease; Carotid intima-media thickness; Female; Genetic predisposition to disease; Human; Hypertension; Male; Mendelian randomization analysis; Middle aged; Phenotype; Pulmonary disease, chronic obstructive; Risk assessment; Risk factor; Switzerland; alpha 1-antitrypsin; alpha 1-antitrypsin deficiency; Mutation
Subject (DDC) : 616: Internal medicine and diseases
Abstract: Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational dust and fumes, genetic A1AT deficiency can cause chronic obstructive pulmonary disease, a condition with elevated cardiovascular risk. The effects of A1AT deficiency on cardiovascular risk have hardly been studied today.
Departement: Health Professions
Organisational Unit: Institute of Health Sciences (IGW)
Publication type: Article in scientific journal
DOI : 10.1016/j.atherosclerosis.2018.01.042
ISSN: 1879-1484
0021-9150
URI: https://digitalcollection.zhaw.ch/handle/11475/17594
Appears in Collections:Publikationen Gesundheit

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