Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers

Erbas, Bircan; Knudsen, Toril Mørkve; Janson, Christer; Nilsen, Roy M.; Accordini, Simone; Benediktdottir, Bryndis; Dratva, Julia; Heinrich, Joachim; Jarvis, Debbie; Leynaert, Benedcite; Matheson, Melanie C.; Norbäck, Dan; Real, Francisco G.; Raherison-Semjen, Chantal; Villani, Simona; Dharmage, S.C.; Svanes, C.

doi:10.1016/j.envres.2018.02.028

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers
Authors:	Erbas, Bircan Knudsen, Toril Mørkve Janson, Christer Nilsen, Roy M. Accordini, Simone Benediktdottir, Bryndis Dratva, Julia Heinrich, Joachim Jarvis, Debbie Leynaert, Benedcite Matheson, Melanie C. Norbäck, Dan Real, Francisco G. Raherison-Semjen, Chantal Villani, Simona Dharmage, S.C. Svanes, C.
et. al:	No
DOI:	10.1016/j.envres.2018.02.028
Published in:	Environmental Research
Volume(Issue):	164
Page(s):	241
Pages to:	247
Issue Date:	2018
Publisher / Ed. Institution:	Elsevier
ISSN:	0013-9351 1096-0953
Language:	English
Subjects:	Asthma; Cigarette smoking; ECRHS; Lung function; Respiratory symptom
Subject (DDC):	616: Internal medicine and diseases
Abstract:	Background: Despite extensive knowledge of smoking effects on respiratory disease, there is no study including all age windows of exposure among ever smokers. The objective of this study was to assess the effects from smoking exposure in utero, early childhood, adolescence and adulthood on respiratory health outcomes in adult male and female ever smokers. Methods: Respiratory health outcomes were assessed in 10,610 participants of the European Community Respiratory Health Survey (ECRHS) I who reported a history of ever smoking by questionnaire. The associations of maternal smoking in utero, maternal smoking during childhood, age of smoking debut and pack-years of smoking with respiratory symptoms, obstructive diseases and bronchial hyperreactivity were analysed using generalized linear regression, non-linearity between age of smoking debut and outcomes were assessed by Generalized additive mixed models. Results: Respiratory symptoms and asthma were more frequent in adults if their mother smoked during pregnancy, and, in men, also if mother smoked in childhood. Wheeze and ≥3 respiratory symptoms declined with later smoking debut among women [≤10 years: OR = 3.51, 95% CI 1.26, 9.73; 11–12 years: 1.57[1.01–2.44]; 13–15 years: 1.11[0.94–1.32] and ≤10 years: 3.74[1.56–8.83]; 11–12 years: 1.76[1.19–2.56]; 13–15 years: 1.12[0.94–1.35], respectively]. Effects of increasing number of packyears were pronounced in women (Chronic Obstructive Pulmonary Disease (COPD): OR/10 packyears women: 1.33 [1.18, 1.50], men: 1.14 [1.04, 1.26] pinteraction = 0.01). Conclusions: Among ever smokers, smoking exposure in each stage of the lifespan show persistent harmful effects for adult respiratory health, while women appeared to be more vulnerable to an early age of smoking debut and amount of smoking in adulthood.
URI:	https://digitalcollection.zhaw.ch/handle/11475/17593
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

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Erbas, B., Knudsen, T. M., Janson, C., Nilsen, R. M., Accordini, S., Benediktdottir, B., Dratva, J., Heinrich, J., Jarvis, D., Leynaert, B., Matheson, M. C., Norbäck, D., Real, F. G., Raherison-Semjen, C., Villani, S., Dharmage, S. C., & Svanes, C. (2018). Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers. Environmental Research, 164, 241–247. https://doi.org/10.1016/j.envres.2018.02.028

Erbas, B. et al. (2018) ‘Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers’, Environmental Research, 164, pp. 241–247. Available at: https://doi.org/10.1016/j.envres.2018.02.028.

B. Erbas et al., “Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers,” Environmental Research, vol. 164, pp. 241–247, 2018, doi: 10.1016/j.envres.2018.02.028.

ERBAS, Bircan, Toril Mørkve KNUDSEN, Christer JANSON, Roy M. NILSEN, Simone ACCORDINI, Bryndis BENEDIKTDOTTIR, Julia DRATVA, Joachim HEINRICH, Debbie JARVIS, Benedcite LEYNAERT, Melanie C. MATHESON, Dan NORBÄCK, Francisco G. REAL, Chantal RAHERISON-SEMJEN, Simona VILLANI, S.C. DHARMAGE und C. SVANES, 2018. Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers. Environmental Research. 2018. Bd. 164, S. 241–247. DOI 10.1016/j.envres.2018.02.028

Erbas, Bircan, Toril Mørkve Knudsen, Christer Janson, Roy M. Nilsen, Simone Accordini, Bryndis Benediktdottir, Julia Dratva, et al. 2018. “Critical Age Windows in the Impact of Lifetime Smoking Exposure on Respiratory Symptoms and Disease among Ever Smokers.” Environmental Research 164: 241–47. https://doi.org/10.1016/j.envres.2018.02.028.

Erbas, Bircan, et al. “Critical Age Windows in the Impact of Lifetime Smoking Exposure on Respiratory Symptoms and Disease among Ever Smokers.” Environmental Research, vol. 164, 2018, pp. 241–47, https://doi.org/10.1016/j.envres.2018.02.028.