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|Title:||Geography of lumbar paravertebral muscle fatty infiltration|
|Authors :||Crawford, Rebecca J.|
Mhuiris, Áine Ni
Bow, Cora C.
Elliott, James M.
Hoggarth, Mark A
|Published in :||Spine|
|Publisher / Ed. Institution :||Lippincott Williams & Wilkins|
|License (according to publishing contract) :||Licence according to publishing contract|
|Type of review:||Peer review (Publication)|
|Subjects :||Paravertebral; Muscle; Multifidus; Low back pain; Disability; Disc degeneration; Phenotype; Fatty infiltration|
|Subject (DDC) :||616.7: Diseases of musculoskeletal system and orthopaedics|
|Abstract:||STUDY DESIGN: Cross-sectional OBJECTIVE.: We quantified fatty infiltration (FI) geography of the lumbar spine to identify whether demographics, temporal low back pain (LBP), and disability influence FI patterns. SUMMARY OF BACKGROUND DATA: Lumbar paravertebral muscle FI has been associated with age, sex, LBP, and disability; yet, FI accumulation patterns are inadequately described to optimise interventions. METHODS: This cross-sectional study employed lumbar axial T1-weighted MRI in 107 Southern-Chinese adults (54 females, 53 males). Single-slices at the vertebral inferior end-plate per lumbar level were measured for quartiled-FI, and analysed against demographics, LBP, and disability (ODI: Oswestry Disability Index). RESULTS: Mean FI% was higher in females, on the right, increased per level caudally, and from medial to lateral in men (p < 0.05). FI linearly increased with age for both sexes (p < 0.01) and was notably higher at L4&5 than L1,2&3 for cases aged 40-65yrs. BMI and FI were unrelated in females and inversely in males (p < 0.001). Females with LBPweek and males with LBPyear had 1.7% (each) less average FI (p < 0.05) than those without pain at that time-point. Men locating their LBP in the back had less FI than those without pain (p < 0.001). Disability was unrelated to FI for both sexes (p > 0.05). CONCLUSIONS: Lumbar paravertebral muscle FI predominates in the lower lumbar spine, notably for those aged 40-65, and depends more on sagittal than transverse distribution. Higher FI in females and differences of mean FI between sexes for BMI, LBP, and disabling ODI suggest sex-differential accumulation patterns. Our study contradicts pain models rationalising lumbar muscle FI and may reflect a normative sex-dependent feature of the natural history of lumbar paravertebral muscles.|
|Organisational Unit:||Institute of Health Sciences (IGW)|
|Publication type:||Article in scientific Journal|
|Restricted until :||2020-07-01|
|Appears in Collections:||Publikationen Gesundheit|
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