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Title: Industrial application of 2-oxoglutarate-dependent oxygenases
Authors : Peters, Christin
Buller, Rebecca
Published in : Catalysts
Volume(Issue) : 9
Issue : 3
Pages : 221
Pages to: 240
Publisher / Ed. Institution : MDPI
Issue Date: 2019
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Type of review: Peer review (Publication)
Language : German
Subject (DDC) : 660.6: Biotechnology
Abstract: C–H functionalization is a chemically challenging but highly desirable transformation. 2-oxoglutarate-dependent oxygenases (2OGXs) are remarkably versatile biocatalysts for the activation of C–H bonds. In nature, they have been shown to accept both small and large molecules carrying out a plethora of reactions, including hydroxylations, demethylations, ring formations, rearrangements, desaturations, and halogenations, making them promising candidates for industrial manufacture. In this review, we describe the current status of 2OGX use in biocatalytic applications concentrating on 2OGX-catalyzed oxyfunctionalization of amino acids and synthesis of antibiotics. Looking forward, continued bioinformatic sourcing will help identify additional, practical useful members of this intriguing enzyme family, while enzyme engineering will pave the way to enhance 2OGX reactivity for non-native substrates.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.3390/catal9030221
ISSN: 2073-4344
Appears in Collections:Publikationen Life Sciences und Facility Management

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