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https://doi.org/10.21256/zhaw-2796| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Industrial application of 2-oxoglutarate-dependent oxygenases |
| Authors: | Peters, Christin Buller, Rebecca |
| DOI: | 10.21256/zhaw-2796 10.3390/catal9030221 |
| Published in: | Catalysts |
| Volume(Issue): | 9 |
| Issue: | 3 |
| Page(s): | 221 |
| Pages to: | 240 |
| Issue Date: | 2019 |
| Publisher / Ed. Institution: | MDPI |
| ISSN: | 2073-4344 |
| Language: | German |
| Subject (DDC): | 660.6: Biotechnology |
| Abstract: | C-H functionalization is a chemically challenging but highly desirable transformation. 2-oxoglutarate-dependent oxygenases (2OGXs) are remarkably versatile biocatalysts for the activation of C-H bonds. In nature, they have been shown to accept both small and large molecules carrying out a plethora of reactions, including hydroxylations, demethylations, ring formations, rearrangements, desaturations, and halogenations, making them promising candidates for industrial manufacture. In this review, we describe the current status of 2OGX use in biocatalytic applications concentrating on 2OGX-catalyzed oxyfunctionalization of amino acids and synthesis of antibiotics. Looking forward, continued bioinformatic sourcing will help identify additional, practical useful members of this intriguing enzyme family, while enzyme engineering will pave the way to enhance 2OGX reactivity for non-native substrates. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/16369 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2019_Peters_Bullers_Industrial application of 2-oxoglutarate-dependent oxygenases_Catalysts.pdf | 1.6 MB | Adobe PDF |  View/Open |
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Peters, C., & Buller, R. (2019). Industrial application of 2-oxoglutarate-dependent oxygenases. Catalysts, 9(3), 221–240. https://doi.org/10.21256/zhaw-2796
Peters, C. and Buller, R. (2019) ‘Industrial application of 2-oxoglutarate-dependent oxygenases’, Catalysts, 9(3), pp. 221–240. Available at: https://doi.org/10.21256/zhaw-2796.
C. Peters and R. Buller, “Industrial application of 2-oxoglutarate-dependent oxygenases,” Catalysts, vol. 9, no. 3, pp. 221–240, 2019, doi: 10.21256/zhaw-2796.
PETERS, Christin und Rebecca BULLER, 2019. Industrial application of 2-oxoglutarate-dependent oxygenases. Catalysts. 2019. Bd. 9, Nr. 3, S. 221–240. DOI 10.21256/zhaw-2796
Peters, Christin, and Rebecca Buller. 2019. “Industrial application of 2-oxoglutarate-dependent oxygenases.” Catalysts 9 (3): 221–40. https://doi.org/10.21256/zhaw-2796.
Peters, Christin, and Rebecca Buller. “Industrial application of 2-oxoglutarate-dependent oxygenases.” Catalysts, vol. 9, no. 3, 2019, pp. 221–40, https://doi.org/10.21256/zhaw-2796.
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