Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells

Jonsdottir, Hulda R.; Delaval, Mathilde; Leni, Zaira; Keller, Alejandro; Brem, Benjamin T.; Siegerist, Frithjof; Schönenberger, David; Durdina, Lukas; Elser, Miriam; Burtscher, Heinz; Liati, Anthi; Geiser, Marianne

doi:10.21256/zhaw-5505

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-5505

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells
Authors:	Jonsdottir, Hulda R. Delaval, Mathilde Leni, Zaira Keller, Alejandro Brem, Benjamin T. Siegerist, Frithjof Schönenberger, David Durdina, Lukas Elser, Miriam Burtscher, Heinz Liati, Anthi Geiser, Marianne
DOI:	10.21256/zhaw-5505 10.1038/s42003-019-0332-7
Published in:	Communications Biology
Volume(Issue):	2
Issue:	90
Issue Date:	2019
Publisher / Ed. Institution:	Nature Publishing Group
ISSN:	2399-3642
Language:	English
Subjects:	Mechanisms of disease; Respiratory tract diseases
Subject (DDC):	363: Environmental and security problems
Abstract:	Aircraft emissions contribute to local and global air pollution. Health effects of particulate matter (PM) from aircraft engines are largely unknown, since controlled cell exposures at relevant conditions are challenging. We examined the toxicity of non-volatile PM (nvPM) emissions from a CFM56-7B26 turbofan, the world's most used aircraft turbine using an unprecedented exposure setup. We combined direct turbine-exhaust sampling under realistic engine operating conditions and the Nano-Aerosol Chamber for In vitro Toxicity to deposit particles onto air-liquid-interface cultures of human bronchial epithelial cells (BEAS-2B) at physiological conditions. We evaluated acute cellular responses after 1-h exposures to diluted exhaust from conventional or alternative fuel combustion. We show that single, short-term exposures to nvPM impair bronchial epithelial cells, and PM from conventional fuel at ground-idle conditions is the most hazardous. Electron microscopy of soot reveals varying reactivity matching the observed cellular responses. Stronger responses at lower mass concentrations suggest that additional metrics are necessary to evaluate health risks of this increasingly important emission source.
URI:	https://digitalcollection.zhaw.ch/handle/11475/16116
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	School of Engineering
Organisational Unit:	Centre for Aviation (ZAV)
Appears in collections:	Publikationen School of Engineering

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Jonsdottir, H. R., Delaval, M., Leni, Z., Keller, A., Brem, B. T., Siegerist, F., Schönenberger, D., Durdina, L., Elser, M., Burtscher, H., Liati, A., & Geiser, M. (2019). Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells. Communications Biology, 2(90). https://doi.org/10.21256/zhaw-5505

Jonsdottir, H.R. et al. (2019) ‘Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells’, Communications Biology, 2(90). Available at: https://doi.org/10.21256/zhaw-5505.

H. R. Jonsdottir et al., “Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells,” Communications Biology, vol. 2, no. 90, 2019, doi: 10.21256/zhaw-5505.

JONSDOTTIR, Hulda R., Mathilde DELAVAL, Zaira LENI, Alejandro KELLER, Benjamin T. BREM, Frithjof SIEGERIST, David SCHÖNENBERGER, Lukas DURDINA, Miriam ELSER, Heinz BURTSCHER, Anthi LIATI und Marianne GEISER, 2019. Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells. Communications Biology. 2019. Bd. 2, Nr. 90. DOI 10.21256/zhaw-5505

Jonsdottir, Hulda R., Mathilde Delaval, Zaira Leni, Alejandro Keller, Benjamin T. Brem, Frithjof Siegerist, David Schönenberger, et al. 2019. “Non-Volatile Particle Emissions from Aircraft Turbine Engines at Ground-Idle Induce Oxidative Stress in Bronchial Cells.” Communications Biology 2 (90). https://doi.org/10.21256/zhaw-5505.

Jonsdottir, Hulda R., et al. “Non-Volatile Particle Emissions from Aircraft Turbine Engines at Ground-Idle Induce Oxidative Stress in Bronchial Cells.” Communications Biology, vol. 2, no. 90, 2019, https://doi.org/10.21256/zhaw-5505.