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dc.contributor.authorRössler, Wulf-
dc.contributor.authorHengartner, Michael Pascal-
dc.contributor.authorAngst, Jules-
dc.contributor.authorAjdacic-Gross, Vladeta-
dc.date.accessioned2019-02-07T08:17:20Z-
dc.date.available2019-02-07T08:17:20Z-
dc.date.issued2012-
dc.identifier.issn0965-2140de_CH
dc.identifier.issn1360-0443de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15120-
dc.description.abstractAims: The aim of the study was to examine the temporal associations between substance use and subclinical psychosis symptoms. Design: Data from a prospective community study sampled within a single cohort over 30 years (1978-2008) were analysed with discrete‐time hazard models. Setting: General population‐based sample. Participants: At initial sampling in 1978 males (n = 292) were 19 and females (n = 299) were 20 years old. Measurements: Two psychosis syndromes representing ‘schizotypal signs’ and ‘schizophrenia nuclear symptoms’ and various substance use variables including cannabis, alcohol, tobacco and multiple‐drug use (i.e. cannabis combined with other drugs). Findings: In bivariate analyses, schizotypal signs were predominantly associated with regular cannabis use in adolescence (OR = 2.29, 95% CI 1.32-3.97). Schizophrenia nuclear symptoms were mainly related to alcohol (OR = 1.84, 95% CI 1.00-3.38) and multiple‐drug use (OR = 2.35, 95% CI 1.38-4.02) during adolescence. Multivariate analyses showed that, in particular, regular cannabis use during adolescence was associated with the occurrence of subsequent schizotypal symptoms over a 30‐year period (OR = 2.60, 95% CI; 1.59-4.23), whereas multiple‐drug use in adolescence was associated predominantly with schizophrenia nuclear symptoms (OR = 1.75, 95% CI 1.01-3.03). Alcohol misuse was only slightly associated with the onset of such symptoms. Conclusions: A significant portion of the occurrence of subclinical psychosis symptoms in adulthood can be attributed to excessive cannabis and multiple‐drug use during adolescence. This is in line with the hypothesis that long‐term sensitization of dopaminergic brain receptors plays a role in developing psychotic symptoms.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofAddictionde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectFemalede_CH
dc.subjectHumansde_CH
dc.subjectMalede_CH
dc.subjectProspective Studiesde_CH
dc.subjectPsychoses, Substance-Inducedde_CH
dc.subjectSchizophreniade_CH
dc.subjectSubstance-Related Disordersde_CH
dc.subjectYoung Adultde_CH
dc.subject.ddc616.89: Psychische Störungen, klinische Psychologie und Psychiatriede_CH
dc.titleLinking substance use with symptoms of subclinical psychosis in a community cohort over 30 yearsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementAngewandte Psychologiede_CH
zhaw.organisationalunitPsychologisches Institut (PI)de_CH
dc.identifier.doi10.1111/j.1360-0443.2011.03760.xde_CH
dc.identifier.pmid22151745de_CH
zhaw.funding.euNode_CH
zhaw.issue6de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end1184de_CH
zhaw.pages.start1174de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume107de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedKlinische Psychologiede_CH
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Rössler, W., Hengartner, M. P., Angst, J., & Ajdacic-Gross, V. (2012). Linking substance use with symptoms of subclinical psychosis in a community cohort over 30 years. Addiction, 107(6), 1174–1184. https://doi.org/10.1111/j.1360-0443.2011.03760.x
Rössler, W. et al. (2012) ‘Linking substance use with symptoms of subclinical psychosis in a community cohort over 30 years’, Addiction, 107(6), pp. 1174–1184. Available at: https://doi.org/10.1111/j.1360-0443.2011.03760.x.
W. Rössler, M. P. Hengartner, J. Angst, and V. Ajdacic-Gross, “Linking substance use with symptoms of subclinical psychosis in a community cohort over 30 years,” Addiction, vol. 107, no. 6, pp. 1174–1184, 2012, doi: 10.1111/j.1360-0443.2011.03760.x.
RÖSSLER, Wulf, Michael Pascal HENGARTNER, Jules ANGST und Vladeta AJDACIC-GROSS, 2012. Linking substance use with symptoms of subclinical psychosis in a community cohort over 30 years. Addiction. 2012. Bd. 107, Nr. 6, S. 1174–1184. DOI 10.1111/j.1360-0443.2011.03760.x
Rössler, Wulf, Michael Pascal Hengartner, Jules Angst, and Vladeta Ajdacic-Gross. 2012. “Linking Substance Use with Symptoms of Subclinical Psychosis in a Community Cohort over 30 Years.” Addiction 107 (6): 1174–84. https://doi.org/10.1111/j.1360-0443.2011.03760.x.
Rössler, Wulf, et al. “Linking Substance Use with Symptoms of Subclinical Psychosis in a Community Cohort over 30 Years.” Addiction, vol. 107, no. 6, 2012, pp. 1174–84, https://doi.org/10.1111/j.1360-0443.2011.03760.x.


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