Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3393
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dc.contributor.authorPietsch-Schmied, Constanze-
dc.contributor.authorHollender, Juliane-
dc.contributor.authorDorusch, Falk-
dc.contributor.authorBurkhardt-Holm, Patricia-
dc.date.accessioned2019-01-29T14:15:24Z-
dc.date.available2019-01-29T14:15:24Z-
dc.date.issued2014-
dc.identifier.issn1573-6822de_CH
dc.identifier.issn0742-2091de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/14723-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractThe worldwide distribution and high bioaccumulation potential of pentachlorophenol (PCP) in aquatic organisms imply a high toxicological impact in aquatic systems. Firstly, our investigations show that, similar to mammalian cell lines, PCP can be metabolized to tetrachlorohydroquinone (TCHQ) in the permanent cell line derived from rainbow trout liver cells (RTL-W1). Moreover, we demonstrate that PCP as well as its metabolite TCHQ is capable of influencing the viability of these cells. Three cell viability assays were performed to assess possible cellular targets of these substances. Thus, the cytotoxicity of the PCP-derivative TCHQ was shown for the first time in a fish cell line. Further investigations revealed the involvement of ROS in the cytotoxicity of PCP and its metabolite TCHQ. The observation of oxidative stress provides a plausible explanation for the increased cytotoxicity at higher concentrations especially for PCP and implies possible mechanisms underlying these observations. In addition, antioxidants such as ascorbic acid and quercetin modulate the detrimental effects of PCP and TCHQ whereby both compounds exacerbate the cytotoxic effects of high PCP and TCHQ concentrations.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofCell Biology and Toxicologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAnimalde_CH
dc.subjectAntioxidantde_CH
dc.subjectAscorbic acidde_CH
dc.subjectCell linede_CH
dc.subjectCell survivalde_CH
dc.subjectFish proteinde_CH
dc.subjectHepatocytede_CH
dc.subjectHydroquinonesde_CH
dc.subjectInhibitory concentration 50de_CH
dc.subjectOncorhynchus mykissde_CH
dc.subjectOxidative stressde_CH
dc.subjectPentachlorophenolde_CH
dc.subjectQuercetinde_CH
dc.subjectReactive oxygen speciede_CH
dc.subjectSuperoxide dismutasede_CH
dc.subjectChemical water pollutantde_CH
dc.subject.ddc571: Physiologie und verwandte Themende_CH
dc.titleCytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidantsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
dc.identifier.doi10.21256/zhaw-3393-
dc.identifier.doi10.1007/s10565-014-9283-4de_CH
dc.identifier.pmid24996998de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end252de_CH
zhaw.pages.start233de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume30de_CH
zhaw.embargo.end2019-07-05de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedAquakultur-Systemede_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Pietsch-Schmied, C., Hollender, J., Dorusch, F., & Burkhardt-Holm, P. (2014). Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants. Cell Biology and Toxicology, 30(4), 233–252. https://doi.org/10.21256/zhaw-3393
Pietsch-Schmied, C. et al. (2014) ‘Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants’, Cell Biology and Toxicology, 30(4), pp. 233–252. Available at: https://doi.org/10.21256/zhaw-3393.
C. Pietsch-Schmied, J. Hollender, F. Dorusch, and P. Burkhardt-Holm, “Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants,” Cell Biology and Toxicology, vol. 30, no. 4, pp. 233–252, 2014, doi: 10.21256/zhaw-3393.
PIETSCH-SCHMIED, Constanze, Juliane HOLLENDER, Falk DORUSCH und Patricia BURKHARDT-HOLM, 2014. Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants. Cell Biology and Toxicology. 2014. Bd. 30, Nr. 4, S. 233–252. DOI 10.21256/zhaw-3393
Pietsch-Schmied, Constanze, Juliane Hollender, Falk Dorusch, and Patricia Burkhardt-Holm. 2014. “Cytotoxic Effects of Pentachlorophenol (PCP) and Its Metabolite Tetrachlorohydroquinone (TCHQ) on Liver Cells Are Modulated by Antioxidants.” Cell Biology and Toxicology 30 (4): 233–52. https://doi.org/10.21256/zhaw-3393.
Pietsch-Schmied, Constanze, et al. “Cytotoxic Effects of Pentachlorophenol (PCP) and Its Metabolite Tetrachlorohydroquinone (TCHQ) on Liver Cells Are Modulated by Antioxidants.” Cell Biology and Toxicology, vol. 30, no. 4, 2014, pp. 233–52, https://doi.org/10.21256/zhaw-3393.


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