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https://doi.org/10.21256/zhaw-3411| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Toxicity of ochratoxin to early life stages of zebrafish (Danio rerio) |
| Authors: | Tschirren, Linda Siebenmann, Seraina Pietsch-Schmied, Constanze |
| DOI: | 10.21256/zhaw-3411 10.3390/toxins10070264 |
| Published in: | Toxins |
| Volume(Issue): | 10 |
| Issue: | 7 |
| Page(s): | 264 |
| Issue Date: | 2018 |
| Publisher / Ed. Institution: | MDPI |
| ISSN: | 2072-6651 2072-6651 |
| Language: | English |
| Subjects: | Embryo toxicity; Heart rate; Mycotoxin; Oxidative stress |
| Subject (DDC): | 577: Ecology 590: Animals (Zoology) |
| Abstract: | Ochratoxin A (OTA) is a known contaminant in fish feed but its effect on fish health remains rather unknown. A study was conducted to investigate the effects of different concentrations of ochratoxin on early life stages of zebrafish (Danio rerio). The tests with ochratoxin A showed a correlation between the exposure to mycotoxin and the amount of damage. The mortality rate and the incidents of embryonal damage was increased by increasing ochratoxin concentrations. The calculations resulted in a lethal concentration for 50% of the embryos (LC50) of 0.29 mg/L and a concentration at which 50% of the animals showed impairment (EC50) of 0.36 mg/L after 96 h of exposure. During the test, reduced heart rates were also observed revealing a clear dose-response relationship. The EC50 determination for this endpoint was 1.26 mg/L after 72 h of exposure. The measurement of oxidative stress was proven to be the most sensitive system to indicate OTA effects on the zebrafish embryos with an EC50 value of 0.067 mg/L after 72 h of exposure. The test validity was given because the control test with 3,4-Dichloroaniline (3,4-D) showed a LC50 value of 2.88 mg after 96 h of exposure which is comparable to the available reference values. According to the current knowledge, these experimental doses did not exceed the environmental concentrations of this ochratoxin A. However, this study raises concerns about the effects of ochratoxin on fish. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/14496 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Natural Resource Sciences (IUNR) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Toxicity of Ochratoxin to Early Life Stages of Zebrafish.pdf | 726.91 kB | Adobe PDF |  View/Open |
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Tschirren, L., Siebenmann, S., & Pietsch-Schmied, C. (2018). Toxicity of ochratoxin to early life stages of zebrafish (Danio rerio). Toxins, 10(7), 264. https://doi.org/10.21256/zhaw-3411
Tschirren, L., Siebenmann, S. and Pietsch-Schmied, C. (2018) ‘Toxicity of ochratoxin to early life stages of zebrafish (Danio rerio)’, Toxins, 10(7), p. 264. Available at: https://doi.org/10.21256/zhaw-3411.
L. Tschirren, S. Siebenmann, and C. Pietsch-Schmied, “Toxicity of ochratoxin to early life stages of zebrafish (Danio rerio),” Toxins, vol. 10, no. 7, p. 264, 2018, doi: 10.21256/zhaw-3411.
TSCHIRREN, Linda, Seraina SIEBENMANN und Constanze PIETSCH-SCHMIED, 2018. Toxicity of ochratoxin to early life stages of zebrafish (Danio rerio). Toxins. 2018. Bd. 10, Nr. 7, S. 264. DOI 10.21256/zhaw-3411
Tschirren, Linda, Seraina Siebenmann, and Constanze Pietsch-Schmied. 2018. “Toxicity of Ochratoxin to Early Life Stages of Zebrafish (Danio Rerio).” Toxins 10 (7): 264. https://doi.org/10.21256/zhaw-3411.
Tschirren, Linda, et al. “Toxicity of Ochratoxin to Early Life Stages of Zebrafish (Danio Rerio).” Toxins, vol. 10, no. 7, 2018, p. 264, https://doi.org/10.21256/zhaw-3411.
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