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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Thermography : high sensitivity and specificity diagnosing contact dermatitis in patch testing
Authors : Anzengruber, Florian
Alotaibi, Fayez
Kaufmann, Lilian S.
Ghosh, Adhideb
Oswald, Martin R.
Maul, Julia-Tatjana
Meier Käppeli, Barbara Katharina
French, Lars E.
Bonmarin, Mathias
Navarini, Alexander A.
DOI : 10.21256/zhaw-3414
Published in : Allergology International
Volume(Issue) : 68
Issue : 2
Issue Date: 2018
Publisher / Ed. Institution : Japanese Society of Allergology
ISSN: 1323-8930
Language : English
Subjects : Allergic contact dermatitis; Contact allergy; Infrared; Irritant contact dermatitis; Patch testing
Subject (DDC) : 616: Internal medicine and diseases
Abstract: Background: Patch testing of contact allergens to diagnose allergic contact dermatitis (ACD) is a traditional, useful tool. The most important decision is the distinction between allergic and irritant reactions, as this has direct implications on diagnosis and management. Our objective was to evaluate a new method of non-contact infrared reading of patch tests. Secondary objectives included a possible correlation between the intensity of the patch test reaction and temperature change. Methods: 420 positive reactions from patients were included in our study. An independent patch test reader assessed the positive reactions and classified them as allergic (of intensity + to +++) or irritant (IR). At the same time, a forward-looking infrared (FLIR) camera attachment for an iPhone was used to acquire infrared thermal images of the patch tests, and images were analyzed using the FLIR ONE app. Results: Allergic patch test reactions were characterized by temperature increases of 0.72 ± 0.67°C compared to surrounding skin. Irritant reactions only resulted in 0.17 ± 0.31 °C temperature increase. The mean temperature difference between the two groups was highly significant (p < 0.0001) and therefore was used to predict the type of contact dermatitis. Conclusions: Thermography is a reliable and effective way to distinguish between allergic and irritant contact dermatitis.
Further description : In Press
Fulltext version : Published version
License (according to publishing contract) : CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement: School of Engineering
Organisational Unit: Institute of Computational Physics (ICP)
Appears in Collections:Publikationen School of Engineering

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