Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes

Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Leupold, Marco; Zahnow, Christian; Rupprecht, Jens; Glöckler, Rainer; Greller, Gerhard; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter

doi:10.1002/cite.201700039

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes
Authors:	Schirmer, Cedric Blaschczok, Katharina Husemann, Ute Leupold, Marco Zahnow, Christian Rupprecht, Jens Glöckler, Rainer Greller, Gerhard Pörtner, Ralf Eibl-Schindler, Regine Eibl, Dieter
DOI:	10.1002/cite.201700039
Published in:	Chemie Ingenieur Technik
Volume(Issue):	89
Issue:	12
Issue Date:	20-Oct-2017
Publisher / Ed. Institution:	Wiley
Publisher / Ed. Institution:	Weinheim
ISSN:	0009-286X 1522-2640
Language:	English
Subject (DDC):	660.6: Biotechnology
Abstract:	An in 2016 published DECHEMA guideline concerning process engineering characterization and a new Escherichia coli model process were utilized for the qualification of two geometrically similar stirred stainless steel bioreactors (30 L and 100 L working volume). The achieved results demonstrate that performing an additional biological model process is a valuable complement to the process engineering characterization. Optical densities of 27 (100 L) and 39 (30 L) were reached in the batch cultivation process.
URI:	https://digitalcollection.zhaw.ch/handle/11475/1431
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Schirmer, C., Blaschczok, K., Husemann, U., Leupold, M., Zahnow, C., Rupprecht, J., Glöckler, R., Greller, G., Pörtner, R., Eibl-Schindler, R., & Eibl, D. (2017). Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes. Chemie Ingenieur Technik, 89(12). https://doi.org/10.1002/cite.201700039

Schirmer, C. et al. (2017) ‘Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes’, Chemie Ingenieur Technik, 89(12). Available at: https://doi.org/10.1002/cite.201700039.

C. Schirmer et al., “Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes,” Chemie Ingenieur Technik, vol. 89, no. 12, Oct. 2017, doi: 10.1002/cite.201700039.

SCHIRMER, Cedric, Katharina BLASCHCZOK, Ute HUSEMANN, Marco LEUPOLD, Christian ZAHNOW, Jens RUPPRECHT, Rainer GLÖCKLER, Gerhard GRELLER, Ralf PÖRTNER, Regine EIBL-SCHINDLER und Dieter EIBL, 2017. Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes. Chemie Ingenieur Technik. 20 Oktober 2017. Bd. 89, Nr. 12. DOI 10.1002/cite.201700039

Schirmer, Cedric, Katharina Blaschczok, Ute Husemann, Marco Leupold, Christian Zahnow, Jens Rupprecht, Rainer Glöckler, et al. 2017. “Standardized Qualification of Stirred Bioreactors for Microbial Biopharmaceutical Production Processes.” Chemie Ingenieur Technik 89 (12). https://doi.org/10.1002/cite.201700039.

Schirmer, Cedric, et al. “Standardized Qualification of Stirred Bioreactors for Microbial Biopharmaceutical Production Processes.” Chemie Ingenieur Technik, vol. 89, no. 12, Oct. 2017, https://doi.org/10.1002/cite.201700039.