Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Peer review (Publikation)
Titel: PHASES score for the management of intracranial aneurysm
Autor/-in: Bijlenga, Philippe
Gondar, Renato
Schilling, Sabine
Morel, Sandrine
Hirsch, Sven
Cuony, Johanna
Corniola, Marco-Vincenzo
Perren, Fabienne
Rüfenacht, Daniel
Schaller, Karl
DOI: 10.1161/STROKEAHA.117.017391
Erschienen in: Stroke: A Journal of Cerebral Circulation
Band(Heft): 48
Heft: 8
Seite(n): 2105
Seiten bis: 2112
Erscheinungsdatum: 2017
Verlag / Hrsg. Institution: Lippincott Williams & Wilkins
ISSN: 0039-2499
1524-4628
Sprache: Englisch
Schlagwörter: Hypertension; Intracranial aneurysm; Probability; Risk; Subarachnoid hemorrhage
Fachgebiet (DDC): 616.8: Neurologie und Krankheiten des Nervensystems
Zusammenfassung: Background and Purpose: The aim of this study is to assess whether the PHASES score allows to (1) match decisions taken by multidisciplinary team whether to observe or intervene, (2) classify patients being diagnosed with a ruptured versus unruptured intracranial aneurysm (UIA), and (3) discriminate patients at low risk of rupture from the population of patients diagnosed with intracranial aneurysm. Methods: Population-based prospective and consecutive data were collected between 2006 and 2014. Patients (n=841) were stratified into 4 groups: stable UIA; growing observed UIA; immediately treated UIA; and aneurysmal subarachnoid hemorrhage (aSAH). All patients initially observed were pooled in a follow-up UIA group; patients from growing observed UIA, immediately treated UIA, and aSAH were pooled in a high risk of rupture group. Results are expressed as median [quartile 1, quartile 3]. Results: PHASES scores of immediately treated UIA patients were significantly higher than follow-up UIA group (5 [3, 7] versus 2 [1, 4]). Patients diagnosed with UIA and PHASES score of >3 were more likely to be treated, and the score ≤3 was predictive for observation (areas under these curves=0.74). Odds of being diagnosed with an aSAH were associated with PHASES score of >3 (UIA, 4 [2, 6]; aSAH, 5 [4, 8]; areas under these curves=0.66). Scores of stable UIA patients were significantly lower than high risk of rupture group (2 [1, 4] versus 5 [4, 7]; stable UIA outcome prediction by PHASES score of ≤3: areas under these curves=0.76). Conclusions: There is a progression of PHASES score between stable UIA, growing observed UIA, immediately treated UIA, and aSAH groups. PHASES score of ≤3 is associated with a low but not negligible likelihood of aneurysm rupture, and specificity of the classifier is low.
URI: https://digitalcollection.zhaw.ch/handle/11475/13615
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): Lizenz gemäss Verlagsvertrag
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Computational Life Sciences (ICLS)
Publiziert im Rahmen des ZHAW-Projekts: AneuX
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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