| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | PHASES score for the management of intracranial aneurysm |
| Autor/-in: | Bijlenga, Philippe Gondar, Renato Schilling, Sabine Morel, Sandrine Hirsch, Sven Cuony, Johanna Corniola, Marco-Vincenzo Perren, Fabienne Rüfenacht, Daniel Schaller, Karl |
| DOI: | 10.1161/STROKEAHA.117.017391 |
| Erschienen in: | Stroke: A Journal of Cerebral Circulation |
| Band(Heft): | 48 |
| Heft: | 8 |
| Seite(n): | 2105 |
| Seiten bis: | 2112 |
| Erscheinungsdatum: | 2017 |
| Verlag / Hrsg. Institution: | Lippincott Williams & Wilkins |
| ISSN: | 0039-2499 1524-4628 |
| Sprache: | Englisch |
| Schlagwörter: | Hypertension; Intracranial aneurysm; Probability; Risk; Subarachnoid hemorrhage |
| Fachgebiet (DDC): | 616.8: Neurologie und Krankheiten des Nervensystems |
| Zusammenfassung: | Background and Purpose: The aim of this study is to assess whether the PHASES score allows to (1) match decisions taken by multidisciplinary team whether to observe or intervene, (2) classify patients being diagnosed with a ruptured versus unruptured intracranial aneurysm (UIA), and (3) discriminate patients at low risk of rupture from the population of patients diagnosed with intracranial aneurysm. Methods: Population-based prospective and consecutive data were collected between 2006 and 2014. Patients (n=841) were stratified into 4 groups: stable UIA; growing observed UIA; immediately treated UIA; and aneurysmal subarachnoid hemorrhage (aSAH). All patients initially observed were pooled in a follow-up UIA group; patients from growing observed UIA, immediately treated UIA, and aSAH were pooled in a high risk of rupture group. Results are expressed as median [quartile 1, quartile 3]. Results: PHASES scores of immediately treated UIA patients were significantly higher than follow-up UIA group (5 [3, 7] versus 2 [1, 4]). Patients diagnosed with UIA and PHASES score of >3 were more likely to be treated, and the score ≤3 was predictive for observation (areas under these curves=0.74). Odds of being diagnosed with an aSAH were associated with PHASES score of >3 (UIA, 4 [2, 6]; aSAH, 5 [4, 8]; areas under these curves=0.66). Scores of stable UIA patients were significantly lower than high risk of rupture group (2 [1, 4] versus 5 [4, 7]; stable UIA outcome prediction by PHASES score of ≤3: areas under these curves=0.76). Conclusions: There is a progression of PHASES score between stable UIA, growing observed UIA, immediately treated UIA, and aSAH groups. PHASES score of ≤3 is associated with a low but not negligible likelihood of aneurysm rupture, and specificity of the classifier is low. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/13615 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Computational Life Sciences (ICLS) |
| Publiziert im Rahmen des ZHAW-Projekts: | AneuX |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Bijlenga, P., Gondar, R., Schilling, S., Morel, S., Hirsch, S., Cuony, J., Corniola, M.-V., Perren, F., Rüfenacht, D., & Schaller, K. (2017). PHASES score for the management of intracranial aneurysm. Stroke: A Journal of Cerebral Circulation, 48(8), 2105–2112. https://doi.org/10.1161/STROKEAHA.117.017391
Bijlenga, P. et al. (2017) ‘PHASES score for the management of intracranial aneurysm’, Stroke: A Journal of Cerebral Circulation, 48(8), pp. 2105–2112. Available at: https://doi.org/10.1161/STROKEAHA.117.017391.
P. Bijlenga et al., “PHASES score for the management of intracranial aneurysm,” Stroke: A Journal of Cerebral Circulation, vol. 48, no. 8, pp. 2105–2112, 2017, doi: 10.1161/STROKEAHA.117.017391.
BIJLENGA, Philippe, Renato GONDAR, Sabine SCHILLING, Sandrine MOREL, Sven HIRSCH, Johanna CUONY, Marco-Vincenzo CORNIOLA, Fabienne PERREN, Daniel RÜFENACHT und Karl SCHALLER, 2017. PHASES score for the management of intracranial aneurysm. Stroke: A Journal of Cerebral Circulation. 2017. Bd. 48, Nr. 8, S. 2105–2112. DOI 10.1161/STROKEAHA.117.017391
Bijlenga, Philippe, Renato Gondar, Sabine Schilling, Sandrine Morel, Sven Hirsch, Johanna Cuony, Marco-Vincenzo Corniola, Fabienne Perren, Daniel Rüfenacht, and Karl Schaller. 2017. “PHASES Score for the Management of Intracranial Aneurysm.” Stroke: A Journal of Cerebral Circulation 48 (8): 2105–12. https://doi.org/10.1161/STROKEAHA.117.017391.
Bijlenga, Philippe, et al. “PHASES Score for the Management of Intracranial Aneurysm.” Stroke: A Journal of Cerebral Circulation, vol. 48, no. 8, 2017, pp. 2105–12, https://doi.org/10.1161/STROKEAHA.117.017391.
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