Title: Integrated planar optical waveguide interferometer biosensors : a comparative review
Authors : Kozma, Peter
Kehl, Florian
Ehrentreich-Förster, Eva
Stamm, Christoph Georg
Bier, Frank F.
Published in : Biosensors and Bioelectronics
Volume(Issue) : 58
Pages : 287
Pages to: 307
Publisher / Ed. Institution : Elsevier
Issue Date: 15-Aug-2014
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (publication)
Language : English
Subjects : Biosensor; Waveguide; Optics
Subject (DDC) : 600: Technology
Abstract: Integrated planar optical waveguide interferometer biosensors are advantageous combinations of evanescent field sensing and optical phase difference measurement methods. By probing the near surface region of a sensor area with the evanescent field, any change of the refractive index of the probed volume induces a phase shift of the guided mode compared to a reference field typically of a mode propagating through the reference arm of the same waveguide structure. The interfering fields of these modes produce an interference signal detected at the sensor׳s output, whose alteration is proportional to the refractive index change. This signal can be recorded, processed and related to e.g. the concentration of an analyte in the solution of interest. Although this sensing principle is relatively simple, studies about integrated planar optical waveguide interferometer biosensors can mostly be found in the literature covering the past twenty years. During these two decades, several members of this sensor family have been introduced, which have remarkably advantageous properties. These entail label-free and non-destructive detection, outstandingly good sensitivity and detection limit, cost-effective and simple production, ability of multiplexing and miniaturization. Furthermore, these properties lead to low reagent consumption, short analysis time and open prospects for point-of-care applications. The present review collects the most relevant developments of the past twenty years categorizing them into two main groups, such as common- and double path waveguide interferometers. In addition, it tries to maintain the historical order as it is possible and it compares the diverse sensor designs in order to reveal not only the development of this field in time, but to contrast the advantages and disadvantages of the different approaches and sensor families, as well.
Departement: School of Engineering
Organisational Unit: Institute of Applied Mathematics and Physics (IAMP)
Publication type: Article in scientific journal
DOI : 10.1016/j.bios.2014.02.049
ISSN: 0956-5663
1873-4235
URI: https://digitalcollection.zhaw.ch/handle/11475/13406
Appears in Collections:Publikationen School of Engineering

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