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  2. School of Management and Law
  3. Publikationen
  4. Publikationen School of Management and Law
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dc.contributor.authorEichler, Klaus-
dc.contributor.authorPuhan, Milo A.-
dc.contributor.authorSteurer, Johann-
dc.contributor.authorBachmann, Lucas M.-
dc.date.accessioned2018-11-15T14:26:43Z-
dc.date.available2018-11-15T14:26:43Z-
dc.date.issued2007-
dc.identifier.issn0002-8703de_CH
dc.identifier.issn1097-6744de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/12835-
dc.description.abstractBackground: Uncertainty exists about the performance of the Framingham risk score when applied in different populations. Objective: We assessed calibration of the Framingham risk score (ie, relationship between predicted and observed coronary event rates) in US and non-US populations free of cardiovascular disease. Methods: We reviewed studies that evaluated the performance of the Framingham risk score to predict first coronary events in a validation cohort, as identified by Medline, EMBASE, BIOSIS, and Cochrane library searches (through August 2005). Two reviewers independently assessed 1496 studies for eligibility, extracted data, and performed quality assessment using predefined forms. Results: We included 25 validation cohorts of different population groups (n = 128000) in our main analysis. Calibration varied over a wide range from under- to overprediction of absolute risk by factors of 0.57 to 2.7. Risk prediction for 7 cohorts (n = 18658) from the United States, Australia, and New Zealand was well calibrated (corresponding figures: 0.87-1.08; for the 5 biggest cohorts). The estimated population risks for first coronary events were strongly associated (goodness of fit: R2 = 0.84) and in good agreement with observed risks (coefficient for predicted risk: h = 0.84; 95% CI 0.41-1.26). In 18 European cohorts (n = 109499), the corresponding figures indicated close association (R2 = 0.72) but substantial overprediction (h = 0.58, 95% CI 0.39-0.77). The risk score was well calibrated on the intercept for both population clusters. Conclusion: The Framingham score is well calibrated to predict first coronary events in populations from the United States, Australia, and New Zealand. Overestimation of absolute risk in European cohorts requires recalibration procedures.de_CH
dc.language.isoende_CH
dc.publisherMosbyde_CH
dc.relation.ispartofAmerican Heart Journalde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titlePrediction of first coronary events with the Framingham score : a systematic reviewde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Management and Lawde_CH
zhaw.organisationalunitWinterthurer Institut für Gesundheitsökonomie (WIG)de_CH
dc.identifier.doi10.1016/j.ahj.2007.02.027de_CH
dc.identifier.pmid17452145de_CH
zhaw.funding.euNode_CH
zhaw.issue5de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end731de_CH
zhaw.pages.start722de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume153de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Eichler, K., Puhan, M. A., Steurer, J., & Bachmann, L. M. (2007). Prediction of first coronary events with the Framingham score : a systematic review. American Heart Journal, 153(5), 722–731. https://doi.org/10.1016/j.ahj.2007.02.027
Eichler, K. et al. (2007) ‘Prediction of first coronary events with the Framingham score : a systematic review’, American Heart Journal, 153(5), pp. 722–731. Available at: https://doi.org/10.1016/j.ahj.2007.02.027.
K. Eichler, M. A. Puhan, J. Steurer, and L. M. Bachmann, “Prediction of first coronary events with the Framingham score : a systematic review,” American Heart Journal, vol. 153, no. 5, pp. 722–731, 2007, doi: 10.1016/j.ahj.2007.02.027.
EICHLER, Klaus, Milo A. PUHAN, Johann STEURER und Lucas M. BACHMANN, 2007. Prediction of first coronary events with the Framingham score : a systematic review. American Heart Journal. 2007. Bd. 153, Nr. 5, S. 722–731. DOI 10.1016/j.ahj.2007.02.027
Eichler, Klaus, Milo A. Puhan, Johann Steurer, and Lucas M. Bachmann. 2007. “Prediction of First Coronary Events with the Framingham Score : A Systematic Review.” American Heart Journal 153 (5): 722–31. https://doi.org/10.1016/j.ahj.2007.02.027.
Eichler, Klaus, et al. “Prediction of First Coronary Events with the Framingham Score : A Systematic Review.” American Heart Journal, vol. 153, no. 5, 2007, pp. 722–31, https://doi.org/10.1016/j.ahj.2007.02.027.


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