| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Prediction of first coronary events with the Framingham score : a systematic review |
| Autor/-in: | Eichler, Klaus Puhan, Milo A. Steurer, Johann Bachmann, Lucas M. |
| DOI: | 10.1016/j.ahj.2007.02.027 |
| Erschienen in: | American Heart Journal |
| Band(Heft): | 153 |
| Heft: | 5 |
| Seite(n): | 722 |
| Seiten bis: | 731 |
| Erscheinungsdatum: | 2007 |
| Verlag / Hrsg. Institution: | Mosby |
| ISSN: | 0002-8703 1097-6744 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | Background: Uncertainty exists about the performance of the Framingham risk score when applied in different populations. Objective: We assessed calibration of the Framingham risk score (ie, relationship between predicted and observed coronary event rates) in US and non-US populations free of cardiovascular disease. Methods: We reviewed studies that evaluated the performance of the Framingham risk score to predict first coronary events in a validation cohort, as identified by Medline, EMBASE, BIOSIS, and Cochrane library searches (through August 2005). Two reviewers independently assessed 1496 studies for eligibility, extracted data, and performed quality assessment using predefined forms. Results: We included 25 validation cohorts of different population groups (n = 128000) in our main analysis. Calibration varied over a wide range from under- to overprediction of absolute risk by factors of 0.57 to 2.7. Risk prediction for 7 cohorts (n = 18658) from the United States, Australia, and New Zealand was well calibrated (corresponding figures: 0.87-1.08; for the 5 biggest cohorts). The estimated population risks for first coronary events were strongly associated (goodness of fit: R2 = 0.84) and in good agreement with observed risks (coefficient for predicted risk: h = 0.84; 95% CI 0.41-1.26). In 18 European cohorts (n = 109499), the corresponding figures indicated close association (R2 = 0.72) but substantial overprediction (h = 0.58, 95% CI 0.39-0.77). The risk score was well calibrated on the intercept for both population clusters. Conclusion: The Framingham score is well calibrated to predict first coronary events in populations from the United States, Australia, and New Zealand. Overestimation of absolute risk in European cohorts requires recalibration procedures. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12835 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | School of Management and Law |
| Organisationseinheit: | Winterthurer Institut für Gesundheitsökonomie (WIG) |
| Enthalten in den Sammlungen: | Publikationen School of Management and Law |
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Eichler, K., Puhan, M. A., Steurer, J., & Bachmann, L. M. (2007). Prediction of first coronary events with the Framingham score : a systematic review. American Heart Journal, 153(5), 722–731. https://doi.org/10.1016/j.ahj.2007.02.027
Eichler, K. et al. (2007) ‘Prediction of first coronary events with the Framingham score : a systematic review’, American Heart Journal, 153(5), pp. 722–731. Available at: https://doi.org/10.1016/j.ahj.2007.02.027.
K. Eichler, M. A. Puhan, J. Steurer, and L. M. Bachmann, “Prediction of first coronary events with the Framingham score : a systematic review,” American Heart Journal, vol. 153, no. 5, pp. 722–731, 2007, doi: 10.1016/j.ahj.2007.02.027.
EICHLER, Klaus, Milo A. PUHAN, Johann STEURER und Lucas M. BACHMANN, 2007. Prediction of first coronary events with the Framingham score : a systematic review. American Heart Journal. 2007. Bd. 153, Nr. 5, S. 722–731. DOI 10.1016/j.ahj.2007.02.027
Eichler, Klaus, Milo A. Puhan, Johann Steurer, and Lucas M. Bachmann. 2007. “Prediction of First Coronary Events with the Framingham Score : A Systematic Review.” American Heart Journal 153 (5): 722–31. https://doi.org/10.1016/j.ahj.2007.02.027.
Eichler, Klaus, et al. “Prediction of First Coronary Events with the Framingham Score : A Systematic Review.” American Heart Journal, vol. 153, no. 5, 2007, pp. 722–31, https://doi.org/10.1016/j.ahj.2007.02.027.
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