| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing |
| Autor/-in: | Peh, Priscilla Lim, Natalie Sheng Jie Blocki, Anna Chee, Stella Min Ling Park, Heyjin Chris Liao, Susan Chan, Casey Raghunath, Michael |
| DOI: | 10.1021/acs.bioconjchem.5b00123 |
| Erschienen in: | Bioconjugate Chemistry |
| Band(Heft): | 26 |
| Heft: | 7 |
| Seite(n): | 1348 |
| Seiten bis: | 1358 |
| Erscheinungsdatum: | 2015 |
| Verlag / Hrsg. Institution: | American Chemical Society |
| ISSN: | 1043-1802 1520-4812 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 572: Biochemie 617: Chirurgie |
| Zusammenfassung: | Blend emulsion electrospinning is widely perceived to destroy the bioactivity of proteins, and a blend emulsion of water-soluble and nonsoluble molecules is believed to be thermodynamically unstable to electrospin smoothly. Here we demonstrate a method to retain the bioactivity of disparate fragile biomolecules when electrospun. Using bovine serum albumin as a carrier protein; water-soluble vitamin C, fat soluble vitamin D3, steroid hormone hydrocortisone, peptide hormone insulin, thyroid hormone triiodothyronine (T3), and peptide epidermal growth factor (EGF) were simultaneously blend-spun into PLGA-collagen nanofibers. Upon release, vitamin C maintained the ability to facilitate Type I collagen secretion by fibroblasts, EGF stimulated skin fibroblast proliferation, and insulin potentiated adipogenic differentiation. Transgenic cell reporter assays confirmed the bioactivity of vitamin D3, T3, and hydrocortisone. These factors concertedly increased keratinocyte and fibroblast proliferation while maintaining keratinocyte basal state. This method presents an elegant solution to simultaneously deliver disparate bioactive biomolecules for wound healing applications. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12203 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Peh, P., Lim, N. S. J., Blocki, A., Chee, S. M. L., Park, H. C., Liao, S., Chan, C., & Raghunath, M. (2015). Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing. Bioconjugate Chemistry, 26(7), 1348–1358. https://doi.org/10.1021/acs.bioconjchem.5b00123
Peh, P. et al. (2015) ‘Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing’, Bioconjugate Chemistry, 26(7), pp. 1348–1358. Available at: https://doi.org/10.1021/acs.bioconjchem.5b00123.
P. Peh et al., “Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing,” Bioconjugate Chemistry, vol. 26, no. 7, pp. 1348–1358, 2015, doi: 10.1021/acs.bioconjchem.5b00123.
PEH, Priscilla, Natalie Sheng Jie LIM, Anna BLOCKI, Stella Min Ling CHEE, Heyjin Chris PARK, Susan LIAO, Casey CHAN und Michael RAGHUNATH, 2015. Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing. Bioconjugate Chemistry. 2015. Bd. 26, Nr. 7, S. 1348–1358. DOI 10.1021/acs.bioconjchem.5b00123
Peh, Priscilla, Natalie Sheng Jie Lim, Anna Blocki, Stella Min Ling Chee, Heyjin Chris Park, Susan Liao, Casey Chan, and Michael Raghunath. 2015. “Simultaneous Delivery of Highly Diverse Bioactive Compounds from Blend Electrospun Fibers for Skin Wound Healing.” Bioconjugate Chemistry 26 (7): 1348–58. https://doi.org/10.1021/acs.bioconjchem.5b00123.
Peh, Priscilla, et al. “Simultaneous Delivery of Highly Diverse Bioactive Compounds from Blend Electrospun Fibers for Skin Wound Healing.” Bioconjugate Chemistry, vol. 26, no. 7, 2015, pp. 1348–58, https://doi.org/10.1021/acs.bioconjchem.5b00123.
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