Titel: Clinical data sharing : a data scientist's perspective
Autor/-in: Juchler, Norman
Schilling, Sabine
Watanabe, Kazuhiro
Anzai, Hitomi
Rüfenacht, Daniel
Bijlenga, Philippe
Kurtcuoglu, Vartan
Hirsch, Sven
Angaben zur Konferenz: Life in Numbers 4, ZHAW, Waedenswil, 4 October 2018
Erscheinungsdatum: 4-Okt-2018
Lizenz (gemäss Verlagsvertrag): Keine Angabe
Art der Begutachtung: Keine Begutachtung
Sprache: Englisch
Schlagwörter: Intracranial aneurysms; Clinical data sharing
Fachgebiet (DDC): 005: Computerprogrammierung, Programme und Daten
610: Medizin und Gesundheit
Zusammenfassung: An ever increasing amount of medical data is collected and used for scientific and clinical purposes. To benefit from the abundance of data, however, one has to deal with several challenges. The diversity of data sources, the variability seen in the biological systems and the biases and distortions inherent in the acquired data request for robust and flexible data processing pipelines. Here, we illustrate some of these challenges at the hand of our research on intracranial aneurysms and share insights how to deal with these challenges. We present the AneuX AneurysmDataBase. It stores data acquired at multiple clinical centers, supports heterogeneous data (clinical data, imaging data, genetic data, morphological and histological data, etc.) and is aimed for use in both scientific and industrial contexts. We further present five scientific studies that demonstrate the usage of the AneurysmDataBase. In the first application, we evaluated the PHASES score, a recent scoring scheme to guide the clinicians whether to treat an unruptured intracranial aneurysm. We further examined and improved existing morphological descriptors with the goal to associate aneurysm shape with its disease status. In a third study, we quantified the qualitative rating of aneurysm shape by humans. A fourth study aims at inferring information about the disease directly from imaging data by means of convolutional neural nets. Finally, we sketch how to query aneurysms with similar anatomical and morphological properties from a database. With our work, we demonstrate how clinical data sharing can be used for quantitative analyses of aneurysm properties and for the development of diagnostic and prognostic tools.
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Angewandte Simulation (IAS)
Publikationstyp: Konferenz: Sonstiges
URI: https://digitalcollection.zhaw.ch/handle/11475/12078
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.


Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.