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dc.contributor.authorJuchler, Norman-
dc.contributor.authorSchilling, Sabine-
dc.contributor.authorVartan, Kurtcuoglu-
dc.contributor.authorHirsch, Sven-
dc.description.abstractThe risk assessment of intracranial aneurysms is an exceedingly difficult task. Clinicians associate aneurysm shape irregularity with disease instability. However, there is no consensus on which shape features reliably predict aneurysm instability. We have adopted a machine learning approach to identify shape features with predictive power for aneurysm instability: From imaging data 3D models of aneurysms are extracted that are used to train a classifier. A variety of representations of the 3D shape are calculated, these include the Zernike moment invariants (ZMI) and geometry indices such as aspect ratio, ellipticity and non-sphericity. The processing pipeline was applied to synthetic data and clinical datasets of 413 aneurysms registered in the AneurysmDataBase (SwissNeuroFoundation) and AneuriskWeb database. Classification based on ZMI alone allowed us to distinguish between sidewall and bifurcation aneurysms, but failed to forecast an aneurysm’s rupture status reliably. Simpler geometry indices performed similarly well in rupture status prediction. On synthetic data we showed that ZMI could encode shape irregularity. It remains to be investigated whether further stratification of the aneurysms in terms of location, size and clinical factors will increase the robustness of the applied classification methods.de_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectShape-based risk assessmentde_CH
dc.subjectIntracranial aneurysmsde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleShape-based assessment of intracranial aneurysm disease statusde_CH
dc.typeKonferenz: Posterde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Angewandte Simulation (IAS)de_CH
zhaw.conference.detailsZNZ Symposium 2016, Zurich, 15 September 2016de_CH
zhaw.publication.reviewNot specifiedde_CH
zhaw.webfeedBiomedical Simulationde_CH
Appears in Collections:Publikationen Life Sciences und Facility Management

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