1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLuginbühl, Vera-
dc.contributor.authorMeier, Nicolas-
dc.contributor.authorKovar, Karin-
dc.contributor.authorRohrer, Jack-
dc.date.accessioned2018-10-09T14:22:32Z-
dc.date.available2018-10-09T14:22:32Z-
dc.date.issued2018-05-
dc.identifier.issn0734-9750de_CH
dc.identifier.issn1873-1899de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/11523-
dc.description.abstractA treasure trove of intracellular cancer drug targets remains hidden behind cell membranes. However, engineered pathogen-derived toxins such as Shiga toxins can deliver small or macromolecular drugs to specific intracellular organelles. After binding to ganglioglobotriaosylceramide (Gb3, CD77), the non-toxic subunit B (StxB) of the Shiga-holotoxin is endocytosed and delivers its payload by a unique retrograde trafficking pathway via the endoplasmic reticulum to the cytosol. This review provides an overview of biomedical applications of StxB-based drug delivery systems in targeted cancer diagnosis and therapy. Biotechnological production of the Stx-material is discussed from the perspective of developing efficacious and safe therapeutics.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofBiotechnology Advancesde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAntibody-drug conjugatesde_CH
dc.subjectBiotechnological productionde_CH
dc.subjectCancer targetingde_CH
dc.subjectIntracellular deliveryde_CH
dc.subjectReceptor-mediated endocytosisde_CH
dc.subjectShiga toxinde_CH
dc.subjectShiga toxin subunit Bde_CH
dc.subjectToxin-drug conjugatesde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleIntracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.biotechadv.2018.02.005de_CH
dc.identifier.pmid29432805de_CH
zhaw.funding.euNode_CH
zhaw.issue3de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end623de_CH
zhaw.pages.start613de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume36de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.
Show simple item record
Luginbühl, V., Meier, N., Kovar, K., & Rohrer, J. (2018). Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy. Biotechnology Advances, 36(3), 613–623. https://doi.org/10.1016/j.biotechadv.2018.02.005
Luginbühl, V. et al. (2018) ‘Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy’, Biotechnology Advances, 36(3), pp. 613–623. Available at: https://doi.org/10.1016/j.biotechadv.2018.02.005.
V. Luginbühl, N. Meier, K. Kovar, and J. Rohrer, “Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy,” Biotechnology Advances, vol. 36, no. 3, pp. 613–623, May 2018, doi: 10.1016/j.biotechadv.2018.02.005.
LUGINBÜHL, Vera, Nicolas MEIER, Karin KOVAR und Jack ROHRER, 2018. Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy. Biotechnology Advances. Mai 2018. Bd. 36, Nr. 3, S. 613–623. DOI 10.1016/j.biotechadv.2018.02.005
Luginbühl, Vera, Nicolas Meier, Karin Kovar, and Jack Rohrer. 2018. “Intracellular Drug Delivery : Potential Usefulness of Engineered Shiga Toxin Subunit B for Targeted Cancer Therapy.” Biotechnology Advances 36 (3): 613–23. https://doi.org/10.1016/j.biotechadv.2018.02.005.
Luginbühl, Vera, et al. “Intracellular Drug Delivery : Potential Usefulness of Engineered Shiga Toxin Subunit B for Targeted Cancer Therapy.” Biotechnology Advances, vol. 36, no. 3, May 2018, pp. 613–23, https://doi.org/10.1016/j.biotechadv.2018.02.005.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.