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Titel: Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?
Autor/-in: Dratva, Julia
Caviezel, Seraina
Schaffner, Emmanuel
Stolz, Daiana
Rothe, Thomas
Kuenzli, Nino
Schmidt-Trucksäss, Arno
Zemp, Elisabeth
Probst-Hensch, Nicole
Erschienen in: European journal of pediatrics
Band(Heft): 177
Heft: 5
Seiten: 699
Seiten bis: 707
Verlag / Hrsg. Institution: Springer
Erscheinungsdatum: 6-Feb-2018
Lizenz (gemäss Verlagsvertrag): Lizenz gemäss Verlagsvertrag
Art der Begutachtung: Peer review (Publikation)
Sprache: Englisch
Schlagwörter: Asthma; Atherosclerosis; Carotid intima media thickness; Epidemiology; Adolescent; Asthma; Atherosclerosis; Carotid Arteries; Child; Cross-Sectional Studies; Female; Humans; Male; Risk Factors; Switzerland; Carotid Intima-Media Thickness; Sex Factors
Fachgebiet (DDC): 616: Innere Medizin und Krankheiten
618.92: Pädiatrie
Zusammenfassung: Respiratory diseases are associated with increased cardiovascular risk in adults, but little is known on the early impact on the vasculature in youth. The SAPALDIA Youth study, the offspring study of the Swiss Study on Air Pollution and Lung and Heart Disease In Adults (SAPALDIA), investigated the association between physician-diagnosed asthma status and common carotid artery intima media thickness (CIMT). Offspring underwent standardized clinical protocols and provided information on early life factors, health, and lifestyle. The association between per subject averages of CIMT and asthma was estimated using mixed linear regression analyses adjusting for main confounders, testing for interaction with gender and age. Of 257 offspring (mean age 15 years, 53% female), 11.5% reported doctor-diagnosed asthma (male 17%, female 7%). Mean CIMT was significantly different by gender (male 0.53 mm (± 0.045), female 0.50 mm (± 0.048); p < 0.001). Interaction was highly significant by gender (p = 0.001) with significantly increased CIMT in asthmatic vs. non-asthmatics boys (difference 0.023 mm, 95% CI 0.003; 0.043), as compared to girls. Conclusion: Our study suggests an increased risk for early vascular change in adolescent asthmatic boys. Whereas the small number of girls limits the interpretation, the result necessitates further research into sex-specific atherosclerotic burden related to respiratory health in adolescence.
Weitere Angaben: Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)
Departement: Gesundheit
Organisationseinheit: Institut für Gesundheitswissenschaften (IGW)
Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
DOI: 10.21256/zhaw-4814
10.1007/s00431-018-3107-0
ISSN: 0340-6199
1432-1076
URI: https://digitalcollection.zhaw.ch/handle/11475/10833
Gesperrt bis: 2023-05-01
Enthalten in den Sammlungen:Publikationen Gesundheit

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