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Title: Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?
Authors : Dratva, Julia
Caviezel, Seraina
Schaffner, Emmanuel
Stolz, Daiana
Rothe, Thomas
Kuenzli, Nino
Schmidt-Trucksäss, Arno
Zemp, Elisabeth
Probst-Hensch, Nicole
Published in : European Journal of Pediatrics
Volume(Issue) : 177
Issue : 5
Pages : 699
Pages to: 707
Publisher / Ed. Institution : Springer
Issue Date: 6-Feb-2018
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (publication)
Language : English
Subjects : Asthma; Atherosclerosis; Carotid intima media thickness; Epidemiology; Adolescent; Asthma; Atherosclerosis; Carotid Arteries; Child; Cross-Sectional Studies; Female; Humans; Male; Risk Factors; Switzerland; Carotid Intima-Media Thickness; Sex Factors
Subject (DDC) : 616: Internal medicine and diseases
618.92: Pediatrics
Abstract: Respiratory diseases are associated with increased cardiovascular risk in adults, but little is known on the early impact on the vasculature in youth. The SAPALDIA Youth study, the offspring study of the Swiss Study on Air Pollution and Lung and Heart Disease In Adults (SAPALDIA), investigated the association between physician-diagnosed asthma status and common carotid artery intima media thickness (CIMT). Offspring underwent standardized clinical protocols and provided information on early life factors, health, and lifestyle. The association between per subject averages of CIMT and asthma was estimated using mixed linear regression analyses adjusting for main confounders, testing for interaction with gender and age. Of 257 offspring (mean age 15 years, 53% female), 11.5% reported doctor-diagnosed asthma (male 17%, female 7%). Mean CIMT was significantly different by gender (male 0.53 mm (± 0.045), female 0.50 mm (± 0.048); p < 0.001). Interaction was highly significant by gender (p = 0.001) with significantly increased CIMT in asthmatic vs. non-asthmatics boys (difference 0.023 mm, 95% CI 0.003; 0.043), as compared to girls. Conclusion: Our study suggests an increased risk for early vascular change in adolescent asthmatic boys. Whereas the small number of girls limits the interpretation, the result necessitates further research into sex-specific atherosclerotic burden related to respiratory health in adolescence.
Further description : Erworben im Rahmen der Schweizer Nationallizenzen (
Departement: Health Professions
Organisational Unit: Institute of Health Sciences (IGW)
Publication type: Article in scientific journal
DOI : 10.21256/zhaw-4814
ISSN: 0340-6199
Restricted until : 2023-05-01
Appears in Collections:Publikationen Gesundheit

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