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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3976
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dc.contributor.authorEichler, Klaus-
dc.contributor.authorUrner, Martin-
dc.contributor.authorTwerenbold, Claudia-
dc.contributor.authorKern, Sabine-
dc.contributor.authorBrügger, Urs-
dc.contributor.authorSpahn, Donat R.-
dc.contributor.authorBeck-Schimmer, Beatrice-
dc.contributor.authorGanter, Michael T.-
dc.date.accessioned2018-09-07T12:50:50Z-
dc.date.available2018-09-07T12:50:50Z-
dc.date.issued2017-
dc.identifier.issn0003-2999de_CH
dc.identifier.issn1526-7598de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/10337-
dc.description.abstractBackground: Pharmacologic pre- and postconditioning with sevoflurane compared with total IV anesthesia in patients undergoing liver surgery reduced complication rates as shown in 2 recent randomized controlled trials. However, the potential health economic consequences of these different anesthesia regimens have not yet been assessed. Methods: An expostcost analysis of these 2 trials in 129 patients treated between 2006 and 2010 was performed. We analyzed direct medical costs for in-hospital stay and compared pharmacologic pre- and postconditioning with sevoflurane (intervention) with total IV anesthesia (control) from the perspective of a Swiss university hospital. Year 2015 costs, converted to US dollars, were derived from hospital cost accounting data and compared with a multivariable regression analysis adjusting for relevant covariables. Costs with negative prefix indicate savings and costs with positive prefix represent higher spending in our analysis. Results: Treatment-related costs per patient showed a nonsignificant change by -12,697 US dollars (95% confidence interval [CI], 10,956 to -36,352; P = 0.29) with preconditioning and by -6139 US dollars (95% CI, 6723 to -19,000; P = 0.35) with postconditioning compared with the control group. Results were robust in our sensitivity analysis. For both procedures (control and intervention) together, major complications led to a significant increase in costs by 86,018 US dollars (95% CI, 13,839-158,198; P = 0.02) per patient compared with patients with no major complications. Conclusions: In this cost analysis, reduced in-hospital costs by pharmacologic conditioning with sevoflurane in patients undergoing liver surgery are suggested. This possible difference in costs compared with total IV anesthesia is the result of reduced complication rates with pharmacologic conditioning, because major complications have significant cost implications.de_CH
dc.language.isoende_CH
dc.publisherLippincott Williams & Wilkinsde_CH
dc.relation.ispartofAnesthesia & Analgesiade_CH
dc.rightshttp://creativecommons.org/licenses/by-nd/4.0/de_CH
dc.subjectAnesthesiade_CH
dc.subjectMethyl etherde_CH
dc.subjectPostoperative complicationde_CH
dc.subjectCost-Benefit analysisde_CH
dc.subject.ddc338: Produktionde_CH
dc.subject.ddc617: Chirurgiede_CH
dc.titleEconomic evaluation of pharmacologic pre- and postconditioning with sevoflurane compared with total intravenous anesthesia in liver surgery : a cost analysisde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Management and Lawde_CH
zhaw.organisationalunitWinterthurer Institut für Gesundheitsökonomie (WIG)de_CH
dc.identifier.doi10.21256/zhaw-3976-
dc.identifier.doi10.1213/ANE.0000000000001814de_CH
dc.identifier.pmid28067701de_CH
zhaw.funding.euNode_CH
zhaw.issue3de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end933de_CH
zhaw.pages.start925de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume124de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.funding.zhawPharmacological pre-/postconditioning in liver surgery: a cost effectiveness studyde_CH
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Eichler, K., Urner, M., Twerenbold, C., Kern, S., Brügger, U., Spahn, D. R., Beck-Schimmer, B., & Ganter, M. T. (2017). Economic evaluation of pharmacologic pre- and postconditioning with sevoflurane compared with total intravenous anesthesia in liver surgery : a cost analysis. Anesthesia & Analgesia, 124(3), 925–933. https://doi.org/10.21256/zhaw-3976
Eichler, K. et al. (2017) ‘Economic evaluation of pharmacologic pre- and postconditioning with sevoflurane compared with total intravenous anesthesia in liver surgery : a cost analysis’, Anesthesia & Analgesia, 124(3), pp. 925–933. Available at: https://doi.org/10.21256/zhaw-3976.
K. Eichler et al., “Economic evaluation of pharmacologic pre- and postconditioning with sevoflurane compared with total intravenous anesthesia in liver surgery : a cost analysis,” Anesthesia & Analgesia, vol. 124, no. 3, pp. 925–933, 2017, doi: 10.21256/zhaw-3976.
EICHLER, Klaus, Martin URNER, Claudia TWERENBOLD, Sabine KERN, Urs BRÜGGER, Donat R. SPAHN, Beatrice BECK-SCHIMMER und Michael T. GANTER, 2017. Economic evaluation of pharmacologic pre- and postconditioning with sevoflurane compared with total intravenous anesthesia in liver surgery : a cost analysis. Anesthesia & Analgesia. 2017. Bd. 124, Nr. 3, S. 925–933. DOI 10.21256/zhaw-3976
Eichler, Klaus, Martin Urner, Claudia Twerenbold, Sabine Kern, Urs Brügger, Donat R. Spahn, Beatrice Beck-Schimmer, and Michael T. Ganter. 2017. “Economic Evaluation of Pharmacologic Pre- and Postconditioning with Sevoflurane Compared with Total Intravenous Anesthesia in Liver Surgery : A Cost Analysis.” Anesthesia & Analgesia 124 (3): 925–33. https://doi.org/10.21256/zhaw-3976.
Eichler, Klaus, et al. “Economic Evaluation of Pharmacologic Pre- and Postconditioning with Sevoflurane Compared with Total Intravenous Anesthesia in Liver Surgery : A Cost Analysis.” Anesthesia & Analgesia, vol. 124, no. 3, 2017, pp. 925–33, https://doi.org/10.21256/zhaw-3976.


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